Co-Ultra PEALut Enhances Endogenous Repair Response Following Moderate Traumatic Brain Injury

• Published in: International journal of molecular sciences Vol. 22; no. 16; p. 8717
• Main Authors: Campolo, Michela, Crupi, Rosalia, Cordaro, Marika, Cardali, Salvatore Massimo, Ardizzone, Alessio, Casili, Giovanna, Scuderi, Sarah Adriana, Siracusa, Rosalba, Esposito, Emanuela, Conti, Alfredo, Cuzzocrea, Salvatore
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 13.08.2021; MDPI
• Subjects: Antioxidants; Apoptosis; Autophagy; Cell cycle; Chemical compounds; Flavonoids; In vivo methods and tests; luteolin; mice; Neurodegeneration; Neurogenesis; Neuronal-glial interactions; Neurotrophic factors; Palmitoylethanolamide; patients; Pharmacology; Repair; Short term memory; Trauma; Traumatic brain injury
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms22168717

This study aimed to assess the neuro-regenerative properties of co-ultramicronized PEALut (Glialia®), composed of palmitoylethanolamide (PEA) and the flavonoid luteolin (Lut), in an in vivo model of traumatic brain injury (TBI) and patients affected by moderate TBI. An increase in neurogenesis was seen in the mice at 72 h and 7 d after TBI. The co-ultra PEALut treatment helped the neuronal reconstitution process to restore the basal level of both novel and mature neurons; moreover, it induced a significant upregulation of the neurotrophic factors, which ultimately led to progress in terms of memory recall during behavioral testing. Moreover, our preliminary findings in a clinical trial suggested that Glialia® treatment facilitated neural recovery on working memory. Thus, co-ultra PEALut (Glialia®) could represent a valuable therapeutic agent for intensifying the endogenous repair response in order to better treat TBI.