Effect of Chronologic Age on Induction of Cystathionine Synthase, Uroporphyrinogen I Synthase, and Glucose-6-phosphate Dehydrogenase Activities in Lymphocytes

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 78; no. 3; pp. 1916 - 1919
• Main Authors: Gartler, Stanley M., Hornung, Sigrid K., Motulsky, Arno G.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 01.03.1981; National Acad Sciences
• Subjects: Adult; Aged; Aging; Ammonia-Lyases - biosynthesis; Cultured cells; Cystathionine beta-Synthase - biosynthesis; Cystathionine beta-Synthase - blood; Dehydrogenases; Enzyme activity; Enzyme Induction; Enzymes; Glucosephosphate Dehydrogenase - biosynthesis; Glucosephosphate Dehydrogenase - blood; Homocystinuria; Humans; Hydro-Lyases - biosynthesis; Hydroxymethylbilane Synthase - biosynthesis; Hydroxymethylbilane Synthase - blood; Leukocytes; Lymphocytes; Lymphocytes - enzymology; Metabolic diseases; Middle Aged; Mitogens; Uroporphyrinogens

The activities of cystathionine synthase [L-serine hydro-lyase (adding homocysteine), EC 4.2.1.22], uroporphyrinogen I synthase [porphobilinogen ammonia-lyase (polymerizing), EC 4.3.1.8], and glucose-6-phosphate dehydrogenase (D-glucose-6-phosphate: NADP+1-oxidoreductase, EC 1.1.1.49) have been meas...