Efficacy of chloroquine-proguanil chemoprophylaxis against malaria in the Central African Republic

• Published in: Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 87; no. 3; pp. 304 - 305
• Main Authors: Garin, D., Lamarque, D., Ringwald, P., Dupuy, O., Chaulet, J.F., Chapalain, J.C., Flechaire, A.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford Elsevier Ltd 01.05.1993; Royal Society of Tropical Medicine and Hygiene; Elsevier
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiparasitic agents; Biological and medical sciences; Chloroquine - therapeutic use; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum - prevention & control; Medical sciences; Pharmacology. Drug treatments; Plasmodium falciparum; Proguanil - therapeutic use; Treatment Outcome; Tropical medicine; Africa; Central African Republic; Human; Infection; Prevention; Protozoa; Antimalarial; Plasmodium falciparum; Protozoal disease; Drug combination; Chemotherapy; Malaria; Efficiency; Sporozoa
• ISSN: 0035-9203; 1878-3503
• DOI: 10.1016/0035-9203(93)90138-G

The extension of resistance of Plasmodium falciparum to chloroquine has forced clinicians to review chemoprophylactic programmes in those regions in Africa where P. falciparum is endemic. The problem is particularly difficult as regards long-term prophylaxis because of the risk of the side effects of antimalarial drugs leading to failure of observance. There is renewed interest in the association of proguanil with chloroquine and the combination has been recommended in France since 1989. Here, we report the results of a study carried out in 1989 and 1990 comparing the efficacy of antimalarial prophylaxis with chloroquine alone with that of combined treatment with proguanil plus chloroquine among French soldiers in the Central African Republic.