Estimate of Opportunistic Prostate Specific Antigen Testing in the Finnish Randomized Study of Screening for Prostate Cancer

• Published in: The Journal of urology Vol. 198; no. 1; pp. 50 - 57
• Main Authors: Kilpeläinen, Tuomas P, Pogodin-Hannolainen, Dimitri, Kemppainen, Kimmo, Talala, Kirsi, Raitanen, Jani, Taari, Kimmo, Kujala, Paula, Tammela, Teuvo L.J, Auvinen, Anssi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2017
• Subjects: Aged; bias; Early Detection of Cancer; Humans; Male; mass screening; Middle Aged; mortality; prostate-specific antigen; Prostate-Specific Antigen - blood; prostatic neoplasms; Prostatic Neoplasms - blood; Reproducibility of Results; Retrospective Studies; Urology; prostate specific antigen; ERSPC; PLCO; SA; PCa; control arm; European Randomized Study of Screening for Prostate Cancer; prostate cancer; screening arm; mass screening; prostatic neoplasms; bias; mortality; Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial; CA; prostate-specific antigen; PSA
• ISSN: 0022-5347; 1527-3792
• DOI: 10.1016/j.juro.2017.01.048

Purpose Screening for prostate cancer remains controversial, although ERSPC (European Randomized Study of Screening for Prostate Cancer) showed a 21% relative reduction in prostate cancer mortality. The Finnish Randomized Study of Screening for Prostate Cancer, which is the largest component of ERSPC, demonstrated a statistically nonsignificant 16% mortality benefit in a separate analysis. The purpose of this study was to estimate the degree of contamination in the control arm of the Finnish trial. Materials and Methods Altogether 48,295 and 31,872 men were randomized to the control and screening arms, respectively. The screening period was 1996 to 2007. The extent of prostate specific antigen testing was analyzed retrospectively using laboratory databases. The incidence of T1c prostate cancer (impalpable prostate cancer detected by elevated prostate specific antigen) was determined from the national Finnish Cancer Registry. Results Approximately 1.4% of men had undergone prostate specific antigen testing 1 to 3 years before randomization. By the first 4, 8 and 12 years of followup 18.1%, 47.7% and 62.7% of men in the control arm had undergone prostate specific antigen testing at least once and in the screening arm the proportions were 69.8%, 81.1% and 85.2%, respectively. The cumulative incidence of T1c prostate cancer was 6.1% in the screening arm and 4.5% in the control arm (RR 1.21, 95% CI 1.13–1.30). Conclusions A large proportion of men in the control arm had undergone a prostate specific antigen test during the 15-year followup. Contamination is likely to dilute differences in prostate cancer mortality between the arms in the Finnish screening trial.