Absence of effect of adjuvant growth hormone therapy on follicular responses to exogenous gonadotropins in women: normal and poor responders

• Published in: Fertility and sterility Vol. 58; no. 5; pp. 919 - 923
• Main Authors: Shaker, Adel G., Fleming, Richard, Jamieson, Mary E., Yates, Robert W.S., Coutts, John R.T.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.11.1992; Elsevier Science
• Subjects: Adult; Biological and medical sciences; Chorionic Gonadotropin - therapeutic use; Estradiol - blood; Female; Follicle Stimulating Hormone - blood; Genital system. Reproduction; Growth hormone; Growth Hormone - administration & dosage; Growth Hormone - therapeutic use; Humans; in vitro fertilization; Infertility, Female - drug therapy; Infertility, Female - physiopathology; Insulin-Like Growth Factor I - metabolism; Medical sciences; Menotropins - administration & dosage; Menotropins - pharmacology; Menotropins - therapeutic use; normal responder patients; Ovarian Follicle - drug effects; Ovarian Follicle - physiopathology; ovarian response; Ovary - drug effects; Ovary - physiopathology; Pharmacology. Drug treatments; poor responder patients; Prospective Studies; in vitro fertilization; poor responder patients; normal responder patients; Growth hormone; ovarian response; Human; Drug combination; HMG; Induction; STH; Gonadotropin; Fecundation; Glycoprotein hormone; HCG; In vitro; Ovulation; Placental hormone; Protein hormone
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/S0015-0282(16)55435-1

To examine the effects of growth hormone (GH) on ovarian responses to exogenous gonadotropins after pituitary desensitization in normal and poor responder patients undergoing in vitro fertilization. A prospective study with comparison of control and GH-treated cycles. Poor responder patients (n=10) required >44 ampules of human menopausal gonadotropin (hMG) to achieve criteria for administration of human chorionic gonadotropin (hCG) on day 0 or cancellation in control cycles, and normal responder patients (n=10) required <45 ampules. Ovarian responses to hMG assessed by duration of stimulation required to achieve first significant estradiol (E2) response and hCG criteria. Total doses and duration of hMG, follicular development and E2 concentrations on day 0, and embryology were also assessed. Growth hormone showed no effect on any of the parameters studied in either patient group. Follicular recruitment, E2 secretion by mature follicles, and oocyte yield and quality were uninfluenced by GH treatment.