Clinical and translational insights on premature ventricular contractions and PVC-induced cardiomyopathy

The medical community's understanding of the consequences of premature ventricular contractions (PVCs) and PVC-induced cardiomyopathy has been derived mostly from observational and large population-based studies. Due to the difficulty of predicting the development of PVC-cardiomyopathy, the acu...

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Bibliographic Details
Published inProgress in cardiovascular diseases Vol. 66; pp. 17 - 27
Main Authors Huizar, Jose F., Tan, Alex Y., Kaszala, Karoly, Ellenbogen, Kenneth A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2021
Subjects
Eccentric hypertrophy
Heart rate irregularity
LV dyssynchrony
Premature atrial contraction
Premature ventricular contraction
RV
MRI
LVEF
CICR
LV
RFA
BP
JPH2
Eccentric hypertrophy
MI
SR
SBP
CHF-STAT
OR
AAD
PACs
CAD
Premature ventricular contraction
PCWP
VAs
SERCA
Premature atrial contraction
PVCs
LV dyssynchrony
LA
SCD
Heart rate irregularity
HF
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Summary:The medical community's understanding of the consequences of premature ventricular contractions (PVCs) and PVC-induced cardiomyopathy has been derived mostly from observational and large population-based studies. Due to the difficulty of predicting the development of PVC-cardiomyopathy, the acute and chronic cardiac effects of PVCs and the mechanism of PVC-cardiomyopathy have been derived from pre-clinical studies with large animal models. Recently, these studies have described myocardial substrates that could potentially increase morbidity and mortality in patients with frequent PVCs and PVC-cardiomyopathy. In this paper, we provide an up-to-date comprehensive review of these pre-clinical and clinical studies.
ISSN:0033-0620
1532-8643
1873-1740
DOI:10.1016/j.pcad.2021.04.001