Longitudinal Study of Bladder Continence in Patients with Spina Bifida in the National Spina Bifida Patient Registry

• Published in: The Journal of urology Vol. 199; no. 3; pp. 837 - 843
• Main Authors: Liu, Tiebin, Ouyang, Lijing, Thibadeau, Judy, Wiener, John S., Routh, Jonathan C., Castillo, Heidi, Castillo, Jonathan, Freeman, Kurt A., Sawin, Kathleen J., Smith, Kathryn, Van Speybroeck, Alexander, Valdez, Rodolfo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2018
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Incidence; longitudinal studies; Male; Middle Aged; Prognosis; Registries; Retrospective Studies; spinal dysraphism; Spinal Dysraphism - complications; Spinal Dysraphism - epidemiology; Time Factors; United States - epidemiology; Urinary Bladder, Neurogenic - epidemiology; Urinary Bladder, Neurogenic - etiology; Urinary Bladder, Neurogenic - physiopathology; Urination - physiology; urologic surgical procedures; Young Adult; United States; spinal dysraphism; MMC; CDC; RSPR; GEE; EAE; ENE; urologic surgical procedures; NSBPR; longitudinal studies; SB
• ISSN: 0022-5347; 1527-3792
• DOI: 10.1016/j.juro.2017.11.048

Achieving bladder continence in individuals with spina bifida is a lifetime management goal. We investigated bladder continence status through time and factors associated with this status in patients with spina bifida. We used National Spina Bifida Patient Registry data collected from 2009 through 2015 and applied generalized estimating equation models to analyze factors associated with bladder continence status. This analysis included 5,250 participants with spina bifida in a large, multi-institutional patient registry who accounted for 12,740 annual clinic visit records during the study period. At last followup mean age was 16.6 years, 22.4% of participants had undergone bladder continence surgery, 92.6% used some form of bladder management and 45.8% reported bladder continence. In a multivariable regression model the likelihood of bladder continence was significantly greater in those who were older, were female, were nonHispanic white, had a nonmyelomeningocele diagnosis, had a lower level of lesion, had a higher mobility level and had private insurance. Continence surgery history and current management were also associated with continence independent of all other factors (adjusted OR and 95% CI 1.9, 1.7–2.1 and 3.8, 3.2–4.6, respectively). The association between bladder management and continence was stronger for those with a myelomeningocele diagnosis (adjusted OR 4.6) than with nonmyelomeningocele (adjusted OR 2.8). In addition to demographic, social and clinical factors, surgical intervention and bladder management are significantly and independently associated with bladder continence status in individuals with spina bifida. The association between bladder management and continence is stronger in those with myelomeningocele.