Methods for the Determination of Selective Androgen Receptor Modulators

The history of the appearance and development of selective androgen receptor modulators (SARMs) is described. The main classes of SARMs and various approaches to their determination are considered. The use of chromatography–mass spectrometry is shown to be promising for the reliable determination of...

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Bibliographic Details
Published inJournal of analytical chemistry (New York, N.Y.) Vol. 75; no. 7; pp. 835 - 850
Main Authors Temerdashev, A. Z., Dmitrieva, E. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.07.2020
Springer
Springer Nature B.V
Subjects
Analytical Chemistry
Androgens
Biological materials
Chemistry
Chemistry and Materials Science
Enzymes
Fearn, John Russell
Laboratory animals
Mass spectrometry
Methods
Modulators
Receptors
Reviews
Testosterone
mass spectrometry
selective androgen receptor modulators
chromatography
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Summary:The history of the appearance and development of selective androgen receptor modulators (SARMs) is described. The main classes of SARMs and various approaches to their determination are considered. The use of chromatography–mass spectrometry is shown to be promising for the reliable determination of SARM traces in various samples. Well-known sample preparation and determination methods in biological materials are considered, and the metabolic pathways the best studied SARM (andarine) using cell cultures (in vitro) and laboratory animals and humans (in vivo) are compared.
ISSN:1061-9348
1608-3199
DOI:10.1134/S1061934820070187