The 9-carboxyl group of pyrroloquinoline quinone, a novel prosthetic group, is essential in the formation of holoenzyme of D-glucose dehydrogenase

Availability of different analogues of pyrroloquinoline quinone as the prosthetic group for apo-D-glucose dehydrogenase was examined. The 9-carboxyl group of pyrroloquinoline quinone was shown to be essential for the reconstitution of the enzyme activity. Although the carboxyl group may not be invol...

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Published inBiochemical and biophysical research communications Vol. 139; no. 3; pp. 1279 - 1284
Main Authors Shinagawa, Emiko, Matsushita, Kazunobu, Nonobe, Masatsugu, Adachi, Osao, Ameyama, Minoru, Ohshiro, Yoshiki, Itoh, Sinobu, Kitamura, Yutaka
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 30.09.1986
Elsevier
Subjects
Applied sciences
Carbohydrate Dehydrogenases - metabolism
Chemical Phenomena
Chemistry
Exact sciences and technology
Glucose 1-Dehydrogenase
Glucose Dehydrogenases - metabolism
Kinetics
Other techniques and industries
PQQ Cofactor
Quinolines - metabolism
PQQ
DCIP
GDH
KPB
EDTA
PMS
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ISSN0006-291X
1090-2104
DOI10.1016/S0006-291X(86)80316-3

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Summary:Availability of different analogues of pyrroloquinoline quinone as the prosthetic group for apo-D-glucose dehydrogenase was examined. The 9-carboxyl group of pyrroloquinoline quinone was shown to be essential for the reconstitution of the enzyme activity. Although the carboxyl group may not be involved in catalytic function, it is quite probable to contribute the binding of the prosthetic group to apoenzyme.
Bibliography:ObjectType-Article-1
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ISSN:0006-291X
1090-2104
DOI:10.1016/S0006-291X(86)80316-3