One-Pot Synthesis of MnOx-SiO2 Porous Composites as Nanozymes with ROS-Scavenging Properties

• Published in: Nanomaterials (Basel, Switzerland) Vol. 12; no. 19; p. 3503
• Main Authors: Garrido, M. Dolores, El Haskouri, Jamal, Marcos, María D., Pérez-Pla, Francisco, Ros-Lis, José Vicente, Amorós, Pedro
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 07.10.2022; MDPI
• Subjects: Adsorption; Catalase; Decomposition reactions; Enzymes; Ethanol; Ligands; Manganese; Manganese oxides; mesoporous; Micelles; Nanocomposites; Nanomaterials; Nanoparticles; Nanotechnology; nanozyme; Needles; Nucleation; Oxidation; Physiology; Polyethylene glycol; Porosity; Porous materials; Potassium; Reaction mechanisms; Reactive oxygen species; Reagents; Scavenging; Silica; Silicon dioxide; Spectrum analysis; superoxide dismutase; Synthesis; X ray photoelectron spectroscopy
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano12193503

The development of nanomaterials that mimic the activity of enzymes is a topic of interest, for the decomposition of reactive oxygen species (ROS). We report the preparation of a novel nanocomposite of MnOx needles covered with SiO2 porous material. The material was prepared in one pot with a two-step procedure. The material was characterized by EDX, SEM, TEM, XRD, nitrogen adsorption–desorption isotherms, and XPS. The synthesis protocol took advantage of the atrane method, favoring the nucleation and initial growth of manganese oxide needles that remained embedded and homogeneously dispersed in a mesoporous silica matrix. The final composite had a high concentration of Mn (Si/Mn molar ratio of ca. 1). The nanozyme presented bimodal porosity: intraparticle and interparticle association with the surfactant micelles and the gaps between silica particles and MnOx needles, respectively. The porosity favored the migration of the reagent to the surface of the catalytic MnOx. The nanozyme showed very efficient SOD and catalase activities, thus improving other materials previously described. The kinetics were studied in detail, and the reaction mechanisms were proposed. It was shown that silica does not play an innocent role in the case of catalase activity, increasing the reaction rate.