GENE DUPLICATION IN SACCHAROMYCES CEREVISIAE

Five independent duplications of the acid-phosphatase (aphtase) structural gene (acp1) were recovered from chemostat populations of S. cerevisiae that were subject to selection for in vivo hyper-aphtase activity. Two of the duplications arose spontaneously. Three of them were induced by UV. All five...

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Published inGenetics (Austin) Vol. 88; no. 4; pp. 673 - 687
Main Authors Hansche, P. E, Beres, V, Lange, P
Format Journal Article
LanguageEnglish
Published United States Genetics Soc America 01.04.1978
Subjects
Acid Phosphatase - genetics
Chromosome Mapping
DNA Replication
Genes
Genetic Linkage
Investigations
Saccharomyces cerevisiae
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Summary:Five independent duplications of the acid-phosphatase (aphtase) structural gene (acp1) were recovered from chemostat populations of S. cerevisiae that were subject to selection for in vivo hyper-aphtase activity. Two of the duplications arose spontaneously. Three of them were induced by UV. All five of the duplication events involved the transpositioning of the aphtase structural gene, acp1, and all known genes distal to acp1 on the right arm of chromosome II, to the terminus of an arm of other unknown chromosomes. One of the five duplicated regions of the right arm of chromosome II was found to be transmitted mitotically and meiotically with very high fidelity. The other four duplicated regions of the right arm of chromosome II were found to be unstable, being lost at a rate of about 2% per mitosis. However, selection for increased fidelity of mitotic transmission was effective in one of these strains. No tandem duplications of the aphtase structural gene were found.
Bibliography:ObjectType-Article-1
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ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/88.4.673