The nature and consequence of vitronectin interaction in the non-compromised contact lens wearing eye

Highlights • Fibroblast cells were used as a probe for on-lens vitronectin mapping. • Higher cell counts were determined on the posterior (versus anterior) lens surface. • The locus of vitronectin on the lens surface is affected by material properties. • Vitronectin deposition will influence plasmin...

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Published inContact lens & anterior eye Vol. 40; no. 4; pp. 228 - 235
Main Authors Cooner, Manpreet, Mann, Aisling, Tighe, Brian
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2017
Subjects
Animals
Biomarkers
Cell Count
Cell Line
Contact Lenses, Hydrophilic
Cornea - metabolism
Deposition
Fibrinolysin - metabolism
Fibroblast cells
Fibroblasts - cytology
Fibroblasts - metabolism
Mice
Models, Animal
Ophthalmology
Post-lens tear film
Tears
Tears - chemistry
Vitronectin - analysis
Biomarkers
Fibroblast cells
Post-lens tear film
Tears
Deposition
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Abstract Highlights • Fibroblast cells were used as a probe for on-lens vitronectin mapping. • Higher cell counts were determined on the posterior (versus anterior) lens surface. • The locus of vitronectin on the lens surface is affected by material properties. • Vitronectin deposition will influence plasmin generation and inflammatory processes.
AbstractList PURPOSEThe aim of this work was to investigate the locus and extent of vitronectin (Vn) deposition on ex vivo contact lenses and to determine the influence of wear modality together with surface and bulk characteristics of the lens material.METHODSThe quantity and location of Vn deposition on the surfaces of contact lens materials was investigated using a novel on-lens cell attachment assay technique.RESULTSVn mapping showed that deposition resulted from lens-corneal interaction rather than solely from the tear film. Higher cell counts on the posterior surface of the lenses were determined in comparison to the anterior surface. Overall gross Vn deposition was greater for high water content-low modulus materials (117±4 average cell count per field) than low water content-high modulus materials (88±6 average cell count per field).CONCLUSIONSThe role of Vn in plasmin regulation and upregulation is widely recognised. The findings in this paper suggest that the locus of Vn on the contact lens surface, which is affected by material properties such as modulus, is potentially an important factor in the generation of plasmin in the posterior tear film. Consequently, the potential for materials to affect Vn deposition will influence lens-induced inflammatory processes.
The aim of this work was to investigate the locus and extent of vitronectin (Vn) deposition on ex vivo contact lenses and to determine the influence of wear modality together with surface and bulk characteristics of the lens material. The quantity and location of Vn deposition on the surfaces of contact lens materials was investigated using a novel on-lens cell attachment assay technique. Vn mapping showed that deposition resulted from lens-corneal interaction rather than solely from the tear film. Higher cell counts on the posterior surface of the lenses were determined in comparison to the anterior surface. Overall gross Vn deposition was greater for high water content-low modulus materials (117±4 average cell count per field) than low water content-high modulus materials (88±6 average cell count per field). The role of Vn in plasmin regulation and upregulation is widely recognised. The findings in this paper suggest that the locus of Vn on the contact lens surface, which is affected by material properties such as modulus, is potentially an important factor in the generation of plasmin in the posterior tear film. Consequently, the potential for materials to affect Vn deposition will influence lens-induced inflammatory processes.
•Fibroblast cells were used as a probe for on-lens vitronectin mapping.•Higher cell counts were determined on the posterior (versus anterior) lens surface.•The locus of vitronectin on the lens surface is affected by material properties.•Vitronectin deposition will influence plasmin generation and inflammatory processes. The aim of this work was to investigate the locus and extent of vitronectin (Vn) deposition on ex vivo contact lenses and to determine the influence of wear modality together with surface and bulk characteristics of the lens material. The quantity and location of Vn deposition on the surfaces of contact lens materials was investigated using a novel on-lens cell attachment assay technique. Vn mapping showed that deposition resulted from lens-corneal interaction rather than solely from the tear film. Higher cell counts on the posterior surface of the lenses were determined in comparison to the anterior surface. Overall gross Vn deposition was greater for high water content-low modulus materials (117±4 average cell count per field) than low water content-high modulus materials (88±6 average cell count per field). The role of Vn in plasmin regulation and upregulation is widely recognised. The findings in this paper suggest that the locus of Vn on the contact lens surface, which is affected by material properties such as modulus, is potentially an important factor in the generation of plasmin in the posterior tear film. Consequently, the potential for materials to affect Vn deposition will influence lens-induced inflammatory processes.
Highlights • Fibroblast cells were used as a probe for on-lens vitronectin mapping. • Higher cell counts were determined on the posterior (versus anterior) lens surface. • The locus of vitronectin on the lens surface is affected by material properties. • Vitronectin deposition will influence plasmin generation and inflammatory processes.
Author Mann, Aisling
Cooner, Manpreet
Tighe, Brian
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Issue 4
Keywords Biomarkers
Fibroblast cells
Post-lens tear film
Tears
Deposition
Language English
License Copyright © 2017 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.
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Snippet Highlights • Fibroblast cells were used as a probe for on-lens vitronectin mapping. • Higher cell counts were determined on the posterior (versus anterior)...
•Fibroblast cells were used as a probe for on-lens vitronectin mapping.•Higher cell counts were determined on the posterior (versus anterior) lens surface.•The...
The aim of this work was to investigate the locus and extent of vitronectin (Vn) deposition on ex vivo contact lenses and to determine the influence of wear...
PURPOSEThe aim of this work was to investigate the locus and extent of vitronectin (Vn) deposition on ex vivo contact lenses and to determine the influence of...
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SubjectTerms Animals
Biomarkers
Cell Count
Cell Line
Contact Lenses, Hydrophilic
Cornea - metabolism
Deposition
Fibrinolysin - metabolism
Fibroblast cells
Fibroblasts - cytology
Fibroblasts - metabolism
Mice
Models, Animal
Ophthalmology
Post-lens tear film
Tears
Tears - chemistry
Vitronectin - analysis
Title The nature and consequence of vitronectin interaction in the non-compromised contact lens wearing eye
URI https://www.clinicalkey.es/playcontent/1-s2.0-S1367048416301308
https://dx.doi.org/10.1016/j.clae.2017.01.005
https://www.ncbi.nlm.nih.gov/pubmed/28236528
https://search.proquest.com/docview/1872574492
Volume 40
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