The nature and consequence of vitronectin interaction in the non-compromised contact lens wearing eye

Highlights • Fibroblast cells were used as a probe for on-lens vitronectin mapping. • Higher cell counts were determined on the posterior (versus anterior) lens surface. • The locus of vitronectin on the lens surface is affected by material properties. • Vitronectin deposition will influence plasmin...

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Bibliographic Details
Published inContact lens & anterior eye Vol. 40; no. 4; pp. 228 - 235
Main Authors Cooner, Manpreet, Mann, Aisling, Tighe, Brian
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2017
Subjects
Animals
Biomarkers
Cell Count
Cell Line
Contact Lenses, Hydrophilic
Cornea - metabolism
Deposition
Fibrinolysin - metabolism
Fibroblast cells
Fibroblasts - cytology
Fibroblasts - metabolism
Mice
Models, Animal
Ophthalmology
Post-lens tear film
Tears
Tears - chemistry
Vitronectin - analysis
Biomarkers
Fibroblast cells
Post-lens tear film
Tears
Deposition
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Summary:Highlights • Fibroblast cells were used as a probe for on-lens vitronectin mapping. • Higher cell counts were determined on the posterior (versus anterior) lens surface. • The locus of vitronectin on the lens surface is affected by material properties. • Vitronectin deposition will influence plasmin generation and inflammatory processes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1367-0484
1476-5411
DOI:10.1016/j.clae.2017.01.005