Voxel-Wise Longitudinal Parametric Response Mapping Analysis of Chest Computed Tomography in Smokers

Chronic obstructive pulmonary disease is a heterogeneous disease characterized by small airway abnormality and emphysema. We hypothesized that a voxel-wise computed tomography analytic approach would identify patterns of disease progression in smokers. We analyzed 725 smokers in spirometric GOLD sta...

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Bibliographic Details
Published inAcademic radiology Vol. 26; no. 2; p. 217
Main Authors Labaki, Wassim W, Gu, Tian, Murray, Susan, Hatt, Charles R, Galbán, Craig J, Ross, Brian D, Martinez, Carlos H, Curtis, Jeffrey L, Hoffman, Eric A, Pompe, Esther, Lynch, David A, Kazerooni, Ella A, Martinez, Fernando J, Han, MeiLan K
Format Journal Article
LanguageEnglish
Published United States 01.02.2019
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Summary:Chronic obstructive pulmonary disease is a heterogeneous disease characterized by small airway abnormality and emphysema. We hypothesized that a voxel-wise computed tomography analytic approach would identify patterns of disease progression in smokers. We analyzed 725 smokers in spirometric GOLD stages 0-4 with two chest CTs 5 years apart. Baseline inspiration, follow-up inspiration and follow-up expiration images were spatially registered to baseline expiration so that each voxel had correspondences across all time points and respiratory phases. Voxel-wise Parametric Response Mapping (PRM) was then generated for the baseline and follow-up scans. PRM classifies lung as normal, functional small airway disease (PRM ), and emphysema (PRM ). Subjects with low baseline PRM and PRM predominantly had an increase in PRM on follow-up; those with higher baseline PRM and PRM mostly had increases in PRM . For GOLD 0 participants (n = 419), mean 5-year increases in PRM and PRM were 0.3% for both; for GOLD 1-4 participants (n = 306), they were 0.6% and 1.6%, respectively. Eighty GOLD 0 subjects (19.1%) had overall radiologic progression (30.0% to PRM , 52.5% to PRM , and 17.5% to both); 153 GOLD 1-4 subjects (50.0%) experienced progression (17.6% to PRM , 48.4% to PRM , and 34.0% to both). In a multivariable model, both baseline PRM and PRM were associated with development of PRM on follow-up, although this relationship was diminished at higher levels of baseline PRM . A voxel-wise longitudinal PRM analytic approach can identify patterns of disease progression in smokers with and without chronic obstructive pulmonary disease.
ISSN:1878-4046
DOI:10.1016/j.acra.2018.05.024