Platelets to surrogate lung inflammation in COVID-19 patients
The neoteric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been jeopardizing the world with the symptoms of seasonal flu. The virus contagion predicted to have been originated from Wuhan, China has by far trapped 4,198,418 cases from 212 countries in the world with two internation...
Saved in:
Published in | Medical hypotheses Vol. 143; p. 110098 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Ltd
01.10.2020
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The neoteric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been jeopardizing the world with the symptoms of seasonal flu. The virus contagion predicted to have been originated from Wuhan, China has by far trapped 4,198,418 cases from 212 countries in the world with two international conveyances with 284,102 deaths as of 11 May 2020 (10:18 GMT). Researchers around the globe have indulged in deciphering viral mode in the body for devising a cure. Affirmations from autopsies and preliminary findings on SARS-CoV-2 hypothesized on viral pathogenesis within the host, for instance, source of inflammation in lungs and pneumonia. This hypothesis assigns the platelets as agents of infection after viral entry. Presently, curbing infection to stall the spread of SARS-CoV-2 is the prima facie intervention employed, worldwide. However, public health authorities must monitor the state of affairs scrupulously, as the deeper our understanding of this novel virus and its associated outbreak, the better we can deal with it. Knowing this idea might be far-fetched, yet this postulate would serve as the groundwork for the present situation. |
---|---|
AbstractList | The neoteric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been jeopardizing the world with the symptoms of seasonal flu. The virus contagion predicted to have been originated from Wuhan, China has by far trapped 4,198,418 cases from 212 countries in the world with two international conveyances with 284,102 deaths as of 11 May 2020 (10:18 GMT). Researchers around the globe have indulged in deciphering viral mode in the body for devising a cure. Affirmations from autopsies and preliminary findings on SARS-CoV-2 hypothesized on viral pathogenesis within the host, for instance, source of inflammation in lungs and pneumonia. This hypothesis assigns the platelets as agents of infection after viral entry. Presently, curbing infection to stall the spread of SARS-CoV-2 is the prima facie intervention employed, worldwide. However, public health authorities must monitor the state of affairs scrupulously, as the deeper our understanding of this novel virus and its associated outbreak, the better we can deal with it. Knowing this idea might be far-fetched, yet this postulate would serve as the groundwork for the present situation. |
ArticleNumber | 110098 |
Author | Pappusamy, Manikantan Meyyazhagan, Arun Kaul, Tanushri Kuchi Bhotla, Haripriya Easwaran, Murugesh Balasubramanian, Balamuralikrishnan Muthupandian, Saravanan Arumugam, Vijaya Anand |
Author_xml | – sequence: 1 givenname: Haripriya surname: Kuchi Bhotla fullname: Kuchi Bhotla, Haripriya organization: Bioknowl Insights Private Limited, Coimbatore, Tamil Nadu 641046, India – sequence: 2 givenname: Tanushri surname: Kaul fullname: Kaul, Tanushri email: tanushri@icgeb.res.in organization: Nutritional Improvement of Crops, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India – sequence: 3 givenname: Balamuralikrishnan surname: Balasubramanian fullname: Balasubramanian, Balamuralikrishnan organization: Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul 05006, Republic of Korea – sequence: 4 givenname: Murugesh surname: Easwaran fullname: Easwaran, Murugesh organization: Nutritional Improvement of Crops, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India – sequence: 5 givenname: Vijaya Anand surname: Arumugam fullname: Arumugam, Vijaya Anand organization: Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, India – sequence: 6 givenname: Manikantan surname: Pappusamy fullname: Pappusamy, Manikantan organization: Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru 560029 (Karnataka), India – sequence: 7 givenname: Saravanan surname: Muthupandian fullname: Muthupandian, Saravanan organization: Department of Medical Microbiology and Immunology, Division of Biomedical Sciences, School of Medicine, College of Health Sciences, Mekelle University, Mekelle 1871, Ethiopia – sequence: 8 givenname: Arun surname: Meyyazhagan fullname: Meyyazhagan, Arun email: arun.meyyazhagan@res.christuniversity.in organization: Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru 560029 (Karnataka), India |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32688185$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kMtKxDAUhoMoOl5ewIV06aZjLs2loIKMVxgYF-o2ZNLTMUPbjEkr-PZmGBXduAr5853_hG8fbXe-A4SOCR4TTMTZctzC68eYYpoCgnGpttCIcEZzKqXcRiPMsMhLJeUe2o9xiRNSMLWL9hgVShHFR-jisTE9NNDHrPdZHELwixRkzdAtMtfVjWlb0zvfpUs2mb08XOekzFYpgq6Ph2inNk2Eo6_zAD3f3jxN7vPp7O5hcjXNbcF5n_OaY0I5rRRQI0QpJMzBVrXChhvOBGPEGgkVzLkAqKVgla0kKbhg1M4VYQfoctO7GuYtVDbtDqbRq-BaEz60N07_fencq174dy0ZLyiXqeD0qyD4twFir1sXLTSN6cAPUdNEqVIWpUoo3aA2-BgD1D9rCNZr73qp19712rveeE9DJ78_-DPyLToB5xsAkqZ3B0FHmxRaqFwA2-vKu__6PwGBTpZa |
CitedBy_id | crossref_primary_10_1007_s10930_021_10019_4 crossref_primary_10_1016_j_jiph_2021_10_010 crossref_primary_10_1055_s_0041_1732836 crossref_primary_10_1186_s12985_023_02152_6 crossref_primary_10_1021_acsptsci_2c00181 crossref_primary_10_1016_j_arr_2021_101513 crossref_primary_10_1038_s41598_020_80120_8 crossref_primary_10_3389_fphar_2021_598925 |
Cites_doi | 10.1016/j.phrs.2017.03.017 10.1038/nature21706 10.1038/s41586-020-2012-7 10.1182/bloodadvances.2017007021 10.21037/atm.2020.02.06 10.1182/blood-2013-09-526277 10.3389/fimmu.2014.00649 10.1007/s15010-020-01401-y 10.1161/ATVBAHA.113.302700 10.1128/JVI.00136-06 10.1038/nrc3004 10.1056/NEJMe2001126 10.1016/j.cca.2020.03.022 |
ContentType | Journal Article |
Copyright | 2020 Elsevier Ltd Copyright © 2020 Elsevier Ltd. All rights reserved. 2020 Elsevier Ltd. All rights reserved. 2020 Elsevier Ltd |
Copyright_xml | – notice: 2020 Elsevier Ltd – notice: Copyright © 2020 Elsevier Ltd. All rights reserved. – notice: 2020 Elsevier Ltd. All rights reserved. 2020 Elsevier Ltd |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
DOI | 10.1016/j.mehy.2020.110098 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1532-2777 |
EndPage | 110098 |
ExternalDocumentID | 10_1016_j_mehy_2020_110098 32688185 S0306987720317163 |
Genre | Letter Correspondence |
GeographicLocations | China |
GeographicLocations_xml | – name: China |
GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29M 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAWTL AAXUO ABBQC ABFNM ABGSF ABJNI ABLJU ABLVK ABMAC ABMZM ABUDA ABXDB ABYKQ ABZDS ACDAQ ACGFS ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AENEX AEVXI AFCTW AFFNX AFKWA AFRHN AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CAG COF CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEA HMK HMO HVGLF HZ~ IHE J1W KOM LCYCR LZ2 M29 M41 MO0 N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SPCBC SSH SSP SSU SSZ T5K UHS WUQ Z5R ZGI ~G- AAXKI AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
ID | FETCH-LOGICAL-c455t-5f501252d8e2a66967ebecdf80a5a536331ca7edeb56eef763dcd7145632cb813 |
IEDL.DBID | AIKHN |
ISSN | 0306-9877 |
IngestDate | Tue Sep 17 21:09:58 EDT 2024 Sat Aug 17 03:32:03 EDT 2024 Thu Sep 26 19:42:18 EDT 2024 Sat Sep 28 08:35:39 EDT 2024 Fri Feb 23 02:48:48 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | COVID-19 Thrombocytopenia Lung inflammation Platelets Pathogenesis |
Language | English |
License | Copyright © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c455t-5f501252d8e2a66967ebecdf80a5a536331ca7edeb56eef763dcd7145632cb813 |
Notes | SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 Equal contribution as a first author. |
OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC7354257 |
PMID | 32688185 |
PQID | 2425897498 |
PQPubID | 23479 |
PageCount | 1 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7354257 proquest_miscellaneous_2425897498 crossref_primary_10_1016_j_mehy_2020_110098 pubmed_primary_32688185 elsevier_sciencedirect_doi_10_1016_j_mehy_2020_110098 |
PublicationCentury | 2000 |
PublicationDate | 2020-10-01 |
PublicationDateYYYYMMDD | 2020-10-01 |
PublicationDate_xml | – month: 10 year: 2020 text: 2020-10-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Medical hypotheses |
PublicationTitleAlternate | Med Hypotheses |
PublicationYear | 2020 |
Publisher | Elsevier Ltd |
Publisher_xml | – name: Elsevier Ltd |
References | Perlman (b0005) 2020; 382 WHO. Coronavirus disease 2019 (COVID-19) situation report – 92. April 22, 2020. Zufferey, Speck, Machlus (b0050) 2017; 1 Zhou, Yang, Wang (b0010) 2020; 579 Mattiuzzi, Lippi (b0025) 2020; 8 Biancardi, Bomfim, Reis, Al-Gassimi, Nunes (b0065) 2017; 120 Gay, Felding-Habermann (b0040) 2011; 11 Antoniak, Mackman (b0075) 2014; 123 Xu, Zhou, Xu (b0070) 2020 Lippi, Plebani, Michael (b0030) 2020; 506 [accessed 22.04.2020]. Chaipan, Soilleux, Simpson (b0060) 2006; 80 Assinger (b0035) 2014; 5 Beaulieu, Lin, Mick (b0055) 2014; 34 Cheng, Shan (b0020) 2020; 48 Lefrançais, Ortiz-Muñoz, Caudrillier (b0045) 2017; 544 Lefrançais (10.1016/j.mehy.2020.110098_b0045) 2017; 544 Biancardi (10.1016/j.mehy.2020.110098_b0065) 2017; 120 Beaulieu (10.1016/j.mehy.2020.110098_b0055) 2014; 34 10.1016/j.mehy.2020.110098_b0015 Zhou (10.1016/j.mehy.2020.110098_b0010) 2020; 579 Assinger (10.1016/j.mehy.2020.110098_b0035) 2014; 5 Xu (10.1016/j.mehy.2020.110098_b0070) 2020 Mattiuzzi (10.1016/j.mehy.2020.110098_b0025) 2020; 8 Zufferey (10.1016/j.mehy.2020.110098_b0050) 2017; 1 Cheng (10.1016/j.mehy.2020.110098_b0020) 2020; 48 Antoniak (10.1016/j.mehy.2020.110098_b0075) 2014; 123 Perlman (10.1016/j.mehy.2020.110098_b0005) 2020; 382 Lippi (10.1016/j.mehy.2020.110098_b0030) 2020; 506 Chaipan (10.1016/j.mehy.2020.110098_b0060) 2006; 80 Gay (10.1016/j.mehy.2020.110098_b0040) 2011; 11 |
References_xml | – volume: 48 start-page: 155 year: 2020 end-page: 163 ident: b0020 article-title: 2019 novel coronavirus: where we are and what we know publication-title: Infection contributor: fullname: Shan – volume: 579 start-page: 270 year: 2020 end-page: 273 ident: b0010 article-title: A pneumonia outbreak associated with a new coronavirus of probable bat origin publication-title: Nature contributor: fullname: Wang – volume: 11 start-page: 123 year: 2011 end-page: 134 ident: b0040 article-title: Contribution of platelets to tumour metastasis publication-title: Nat Rev Cancer contributor: fullname: Felding-Habermann – start-page: 1 year: 2020 end-page: 4 ident: b0070 article-title: Mechanism of thrombocytopenia in COVID-19 patients publication-title: Ann Hematol contributor: fullname: Xu – volume: 382 start-page: 760 year: 2020 end-page: 762 ident: b0005 article-title: Another decade, another coronavirus publication-title: N Engl J Med contributor: fullname: Perlman – volume: 8 start-page: 48 year: 2020 ident: b0025 article-title: Which lessons shall we learn from the 2019 novel coronavirus outbreak? publication-title: Ann Transl Med contributor: fullname: Lippi – volume: 80 start-page: 8951 year: 2006 end-page: 8960 ident: b0060 article-title: DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets publication-title: J Virol contributor: fullname: Simpson – volume: 544 start-page: 105 year: 2017 end-page: 109 ident: b0045 article-title: The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors publication-title: Nature contributor: fullname: Caudrillier – volume: 1 start-page: 1773 year: 2017 end-page: 1785 ident: b0050 article-title: Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets publication-title: Blood Adv contributor: fullname: Machlus – volume: 34 start-page: 552 year: 2014 end-page: 564 ident: b0055 article-title: Interleukin 1 receptor 1 and interleukin 1β regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans publication-title: Arterioscler Thromb Vasc Biol contributor: fullname: Mick – volume: 506 start-page: 145 year: 2020 end-page: 148 ident: b0030 article-title: Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis publication-title: Clin Chim Acta contributor: fullname: Michael – volume: 123 start-page: 2605 year: 2014 end-page: 2613 ident: b0075 article-title: Multiple roles of the coagulation protease cascade during virus infection publication-title: Blood contributor: fullname: Mackman – volume: 120 start-page: 88 year: 2017 end-page: 96 ident: b0065 article-title: The interplay between Angiotensin II, TLR4 and hypertension publication-title: Pharmacol Res contributor: fullname: Nunes – volume: 5 start-page: 649 year: 2014 ident: b0035 article-title: Platelets and infection – an emerging role of platelets in viral infection publication-title: Front Immunol contributor: fullname: Assinger – volume: 120 start-page: 88 year: 2017 ident: 10.1016/j.mehy.2020.110098_b0065 article-title: The interplay between Angiotensin II, TLR4 and hypertension publication-title: Pharmacol Res doi: 10.1016/j.phrs.2017.03.017 contributor: fullname: Biancardi – volume: 544 start-page: 105 year: 2017 ident: 10.1016/j.mehy.2020.110098_b0045 article-title: The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors publication-title: Nature doi: 10.1038/nature21706 contributor: fullname: Lefrançais – volume: 579 start-page: 270 year: 2020 ident: 10.1016/j.mehy.2020.110098_b0010 article-title: A pneumonia outbreak associated with a new coronavirus of probable bat origin publication-title: Nature doi: 10.1038/s41586-020-2012-7 contributor: fullname: Zhou – volume: 1 start-page: 1773 year: 2017 ident: 10.1016/j.mehy.2020.110098_b0050 article-title: Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets publication-title: Blood Adv doi: 10.1182/bloodadvances.2017007021 contributor: fullname: Zufferey – volume: 8 start-page: 48 issue: 3 year: 2020 ident: 10.1016/j.mehy.2020.110098_b0025 article-title: Which lessons shall we learn from the 2019 novel coronavirus outbreak? publication-title: Ann Transl Med doi: 10.21037/atm.2020.02.06 contributor: fullname: Mattiuzzi – volume: 123 start-page: 2605 year: 2014 ident: 10.1016/j.mehy.2020.110098_b0075 article-title: Multiple roles of the coagulation protease cascade during virus infection publication-title: Blood doi: 10.1182/blood-2013-09-526277 contributor: fullname: Antoniak – volume: 5 start-page: 649 year: 2014 ident: 10.1016/j.mehy.2020.110098_b0035 article-title: Platelets and infection – an emerging role of platelets in viral infection publication-title: Front Immunol doi: 10.3389/fimmu.2014.00649 contributor: fullname: Assinger – start-page: 1 year: 2020 ident: 10.1016/j.mehy.2020.110098_b0070 article-title: Mechanism of thrombocytopenia in COVID-19 patients publication-title: Ann Hematol contributor: fullname: Xu – volume: 48 start-page: 155 issue: 2 year: 2020 ident: 10.1016/j.mehy.2020.110098_b0020 article-title: 2019 novel coronavirus: where we are and what we know publication-title: Infection doi: 10.1007/s15010-020-01401-y contributor: fullname: Cheng – volume: 34 start-page: 552 year: 2014 ident: 10.1016/j.mehy.2020.110098_b0055 article-title: Interleukin 1 receptor 1 and interleukin 1β regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.113.302700 contributor: fullname: Beaulieu – volume: 80 start-page: 8951 year: 2006 ident: 10.1016/j.mehy.2020.110098_b0060 article-title: DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets publication-title: J Virol doi: 10.1128/JVI.00136-06 contributor: fullname: Chaipan – ident: 10.1016/j.mehy.2020.110098_b0015 – volume: 11 start-page: 123 year: 2011 ident: 10.1016/j.mehy.2020.110098_b0040 article-title: Contribution of platelets to tumour metastasis publication-title: Nat Rev Cancer doi: 10.1038/nrc3004 contributor: fullname: Gay – volume: 382 start-page: 760 issue: 8 year: 2020 ident: 10.1016/j.mehy.2020.110098_b0005 article-title: Another decade, another coronavirus publication-title: N Engl J Med doi: 10.1056/NEJMe2001126 contributor: fullname: Perlman – volume: 506 start-page: 145 year: 2020 ident: 10.1016/j.mehy.2020.110098_b0030 article-title: Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis publication-title: Clin Chim Acta doi: 10.1016/j.cca.2020.03.022 contributor: fullname: Lippi |
SSID | ssj0009438 |
Score | 2.3708584 |
Snippet | The neoteric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been jeopardizing the world with the symptoms of seasonal flu. The virus... |
SourceID | pubmedcentral proquest crossref pubmed elsevier |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 110098 |
SubjectTerms | Betacoronavirus Blood Platelets - virology China Coronavirus Infections - blood COVID-19 Cytokines - metabolism Humans Inflammation - blood Inflammation - virology Letter to Editors Lung - virology Lung inflammation Megakaryocytes - virology Pandemics Pathogenesis Platelets Pneumonia, Viral - blood SARS-CoV-2 Thrombocytopenia |
Title | Platelets to surrogate lung inflammation in COVID-19 patients |
URI | https://dx.doi.org/10.1016/j.mehy.2020.110098 https://www.ncbi.nlm.nih.gov/pubmed/32688185 https://search.proquest.com/docview/2425897498 https://pubmed.ncbi.nlm.nih.gov/PMC7354257 |
Volume | 143 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT8MwDLbGJiEuiDfjMRWJGwpb1yRtDxzQYBogHhIMcYuaNhVD0KE9Dlz47dhrOhgIDhzbJlL02bE_N7YDsM_dhnbjxGcavS3jsdRMc18yKcIkTnmAHoTqnS-vZKfLzx_EQwlaRS0MpVVa25_b9Im1tm_qFs36a69XvyW2ixEznSNSzxdvDirojjgvQ-X47KJz9dl7l08utKbxjCbY2pk8zevFPL5hmNicJMQ3wuA3__STf35Po_zil9pLsGgJpXOcr3kZSiZbgflLe2S-Ckc3z0gnUTpDZ9R3huPBoE9_zpxn3OUOqhdqRF69iA9O6_r-7IS5oWPbrQ7XoNs-vWt1mL0zgcVciBETqUCXI5pJYJqRlKH0SUpJGjQiEQlPep4bR75JjBbSmBStS4KScpFGec1YB663DuWsn5lNcHjqh7j_MQLUKU-1jGIqesWpPsZQnnarcFAgpV7z1hiqyBl7UoSrIlxVjmsVRAGmmhGwQtv957y9AnmFmk_HGVFm-uOhomApwHCIxmzkkpiuA0lpQFSkCv6MjKYDqKv27Jes9zjpru17guzY1j_Xuw0L9JTn--1AeTQYm13kLSNdg7nDd7dmtfMDOOHr1g |
link.rule.ids | 230,315,786,790,891,4521,24144,27955,27956,45618,45712 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JTsMwEB2xSMAFsVPWIHFDpk1jO8mBAyqgFtqCxKLerDhx1CJIUZcDF76dmSxAQXDgmHgsWW_sWeI3E4BDble0HUYu0-htGQ-lZpq7kknhR2HMPfQgVO_casv6Pb_siM4U1IpaGKJV5rY_s-mptc7flHM0yy-9XvmWol3MmOkekXq-ONMwS9EA8bqO3z55Hj5Pf2dN0ozE88qZjOT1bLqvmCRWUzp8xfd-804_o8_vJMovXuliCRbzcNI6zVa8DFMmWYG5Vn5hvgonN08YTKJuhtaobw3Hg0GfvptZT3jGLdxcuB-y2kV8sGrXD40zZvtW3mx1uAb3F-d3tTrL_5jAQi7EiIlYoMMR1cgz1UBKX7qkoyj2KoEIhCMdxw4D10RGC2lMjLYlQj3ZCJtTDbVnO-swk_QTswkWj10fTz_mfzrmsZZBSCWvONXFDMrRdgmOCqTUS9YYQxWMsUdFuCrCVWW4lkAUYKoJ9Sq03H_OOyiQV7jv6TIjSEx_PFSUKnmYDJHMRqaJj3VgSOpRIFICd0JHHwLUU3tyJOl1097ariPIim39c737MF-_azVVs9G-2oYFGsmYfzswMxqMzS5GMCO9l-7Qd1B_7Ks |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Platelets+to+surrogate+lung+inflammation+in+COVID-19+patients&rft.jtitle=Medical+hypotheses&rft.au=Kuchi+Bhotla%2C+Haripriya&rft.au=Kaul%2C+Tanushri&rft.au=Balasubramanian%2C+Balamuralikrishnan&rft.au=Easwaran%2C+Murugesh&rft.date=2020-10-01&rft.eissn=1532-2777&rft.volume=143&rft.spage=110098&rft.epage=110098&rft_id=info:doi/10.1016%2Fj.mehy.2020.110098&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0306-9877&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0306-9877&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0306-9877&client=summon |