Platelets to surrogate lung inflammation in COVID-19 patients

The neoteric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been jeopardizing the world with the symptoms of seasonal flu. The virus contagion predicted to have been originated from Wuhan, China has by far trapped 4,198,418 cases from 212 countries in the world with two internation...

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Published inMedical hypotheses Vol. 143; p. 110098
Main Authors Kuchi Bhotla, Haripriya, Kaul, Tanushri, Balasubramanian, Balamuralikrishnan, Easwaran, Murugesh, Arumugam, Vijaya Anand, Pappusamy, Manikantan, Muthupandian, Saravanan, Meyyazhagan, Arun
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.10.2020
Subjects
Betacoronavirus
Blood Platelets - virology
China
Coronavirus Infections - blood
COVID-19
Cytokines - metabolism
Humans
Inflammation - blood
Inflammation - virology
Letter to Editors
Lung - virology
Lung inflammation
Megakaryocytes - virology
Pandemics
Pathogenesis
Platelets
Pneumonia, Viral - blood
SARS-CoV-2
Thrombocytopenia
China
COVID-19
Thrombocytopenia
Lung inflammation
Platelets
Pathogenesis
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Abstract The neoteric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been jeopardizing the world with the symptoms of seasonal flu. The virus contagion predicted to have been originated from Wuhan, China has by far trapped 4,198,418 cases from 212 countries in the world with two international conveyances with 284,102 deaths as of 11 May 2020 (10:18 GMT). Researchers around the globe have indulged in deciphering viral mode in the body for devising a cure. Affirmations from autopsies and preliminary findings on SARS-CoV-2 hypothesized on viral pathogenesis within the host, for instance, source of inflammation in lungs and pneumonia. This hypothesis assigns the platelets as agents of infection after viral entry. Presently, curbing infection to stall the spread of SARS-CoV-2 is the prima facie intervention employed, worldwide. However, public health authorities must monitor the state of affairs scrupulously, as the deeper our understanding of this novel virus and its associated outbreak, the better we can deal with it. Knowing this idea might be far-fetched, yet this postulate would serve as the groundwork for the present situation.
AbstractList The neoteric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been jeopardizing the world with the symptoms of seasonal flu. The virus contagion predicted to have been originated from Wuhan, China has by far trapped 4,198,418 cases from 212 countries in the world with two international conveyances with 284,102 deaths as of 11 May 2020 (10:18 GMT). Researchers around the globe have indulged in deciphering viral mode in the body for devising a cure. Affirmations from autopsies and preliminary findings on SARS-CoV-2 hypothesized on viral pathogenesis within the host, for instance, source of inflammation in lungs and pneumonia. This hypothesis assigns the platelets as agents of infection after viral entry. Presently, curbing infection to stall the spread of SARS-CoV-2 is the prima facie intervention employed, worldwide. However, public health authorities must monitor the state of affairs scrupulously, as the deeper our understanding of this novel virus and its associated outbreak, the better we can deal with it. Knowing this idea might be far-fetched, yet this postulate would serve as the groundwork for the present situation.
ArticleNumber 110098
Author Pappusamy, Manikantan
Meyyazhagan, Arun
Kaul, Tanushri
Kuchi Bhotla, Haripriya
Easwaran, Murugesh
Balasubramanian, Balamuralikrishnan
Muthupandian, Saravanan
Arumugam, Vijaya Anand
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10.1038/nature21706
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Keywords COVID-19
Thrombocytopenia
Lung inflammation
Platelets
Pathogenesis
Language English
License Copyright © 2020 Elsevier Ltd. All rights reserved.
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
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Snippet The neoteric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been jeopardizing the world with the symptoms of seasonal flu. The virus...
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StartPage 110098
SubjectTerms Betacoronavirus
Blood Platelets - virology
China
Coronavirus Infections - blood
COVID-19
Cytokines - metabolism
Humans
Inflammation - blood
Inflammation - virology
Letter to Editors
Lung - virology
Lung inflammation
Megakaryocytes - virology
Pandemics
Pathogenesis
Platelets
Pneumonia, Viral - blood
SARS-CoV-2
Thrombocytopenia
Title Platelets to surrogate lung inflammation in COVID-19 patients
URI https://dx.doi.org/10.1016/j.mehy.2020.110098
https://www.ncbi.nlm.nih.gov/pubmed/32688185
https://search.proquest.com/docview/2425897498
https://pubmed.ncbi.nlm.nih.gov/PMC7354257
Volume 143
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