Predisposing factors for pancreatic adenocarcinoma: What is the role of imaging?

• Published in: Diagnostic and interventional imaging Vol. 97; no. 12; pp. 1233 - 1240
• Main Authors: Vullierme, M.-P, Lagadec, M
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.12.2016
• Subjects: Adenocarcinoma - diagnostic imaging; Adenocarcinoma - epidemiology; Adenocarcinoma in Situ - diagnostic imaging; Adenocarcinoma in Situ - epidemiology; Adenocarcinoma in Situ - etiology; Carcinoma, Pancreatic Ductal - diagnostic imaging; Carcinoma, Pancreatic Ductal - epidemiology; Causality; Cholangiopancreatography, Endoscopic Retrograde; Cholangiopancreatography, Magnetic Resonance; Guideline Adherence; Humans; IPMN; Magnetic Resonance Imaging; Mass Screening; MRI; Pancreas adenocarcinoma; Pancreatic Neoplasms - diagnostic imaging; Pancreatic Neoplasms - epidemiology; PanIN; Precancerous Conditions - diagnostic imaging; Precancerous Conditions - epidemiology; Precancerous Conditions - etiology; Radiology; Tomography, X-Ray Computed; CT; IPMN; MRI; Pancreas adenocarcinoma; PanIN
• ISSN: 2211-5684; 2211-5684
• DOI: 10.1016/j.diii.2016.08.018

Abstract Early detection of pancreatic adenocarcinoma is the goal of imaging, enabling curative surgery. The identification of high-grade dysplastic precursor lesions is even more beneficial. Two forms are now better known: pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN). To detect these lesions with imaging, we need to know the patterns associated with them. A screening program could then be used to pinpoint them. This program could not be applied to the entire population. Identifying patients with an increased risk of pancreas adenocarcinoma is the first step of such screening.