The Ubiquitin System: An Emerging Therapeutic Target for Lung Cancer

• Published in: International journal of molecular sciences Vol. 22; no. 17; p. 9629
• Main Authors: Jin, Jun-O, Puranik, Nidhi, Bui, Quyen Thu, Yadav, Dhananjay, Lee, Peter Chang-Whan
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2021; MDPI
• Subjects: Autophagy; Cancer therapies; Cell cycle; Cell signaling; Chronic obstructive pulmonary disease; deubiquitination; DNA repair; E3 ligase; Enzymes; Eukaryotes; Homeostasis; Immune response; Kinases; Lung cancer; Metabolism; Metastases; Mutation; Protein transport; Protein turnover; Proteins; Review; Signal transduction; Therapeutic targets; Ubiquitin; Ubiquitination
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms22179629

The ubiquitin system, present in all eukaryotes, contributes to regulating multiple types of cellular protein processes such as cell signaling, cell cycle, and receptor trafficking, and it affects the immune response. In most types of cancer, unusual events in ubiquitin-mediated signaling pathway modulation can lead to a variety of clinical outcomes, including tumor formation and metastasis. Similarly, ubiquitination acts as a core component, which contributes to the alteration of cell signaling activity, dictating biosignal turnover and protein fates. As lung cancer acquires the most commonly mutated proteins, changes in the ubiquitination of the proteins contribute to the development of lung cancer. Various inhibitors targeting the ubiquitin system have been developed for clinical applications in lung cancer treatment. In this review, we summarize the current research advances in therapeutics for lung cancer by targeting the ubiquitin system.