Clinical significance of jejunoileal involvement of non-Hodgkin’s lymphoma detected by double-balloon enteroscopy

• Published in: International journal of hematology Vol. 97; no. 3; pp. 369 - 381
• Main Authors: Ibuka, Takashi, Tsurumi, Hisashi, Araki, Hiroshi, Hara, Takeshi, Onogi, Fumito, Goto, Naoe, Kojima, Yasushi, Kanemura, Nobuhiro, Shiraki, Makoto, Kasahara, Senji, Shimizu, Masahito, Ogawa, Kengo, Ninomiya, Soranobu, Nakanishi, Takayuki, Kato, Tomohiro, Takami, Tsuyoshi, Moriwaki, Hisataka
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.03.2013; Springer; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Disease-Free Survival; Double-Balloon Enteroscopy; Female; Hematologic and hematopoietic diseases; Hematology; Humans; Jejunal Neoplasms - mortality; Jejunal Neoplasms - pathology; Jejunal Neoplasms - therapy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, Non-Hodgkin - mortality; Lymphoma, Non-Hodgkin - pathology; Lymphoma, Non-Hodgkin - therapy; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Oncology; Original Article; Positron-Emission Tomography; Prospective Studies; Survival Rate; Tomography, X-Ray Computed; Non-Hodgkin’s lymphoma; Prognostic factor; Double-balloon enteroscopy (DBE); Jejunoileum; Jejunoileal; Prognosis; Hematology; Lymphoproliferative syndrome; Malignant hemopathy; Non Hodgkin lymphoma; Non-Hodgkin's lymphoma; Cancer
• ISSN: 0925-5710; 1865-3774
• DOI: 10.1007/s12185-013-1273-4

Jejunoileal involvement of non-Hodgkin’s lymphoma (NHL) is an important diagnostic factor in determining optimal treatment strategies. Here, we used double-balloon enteroscopy (DBE) to detect jejunoileal involvement of NHL and studied its clinical significance in a series of patients with NHL. Adults aged between 18 and 85 years with infiltration of the stomach, duodenum, or colon confirmed by gastrointestinal endoscopy or colonoscopy, suspected jejunoileal involvement determined by CT or FDG-PET, or any other gastrointestinal symptoms, were eligible for inclusion in the study. Among 428 patients with histologically confirmed NHL between 2004 and 2011, 83 were eligible for DBE, but 20 patients were excluded due to rejection or poor clinical status. Thus, 63 underwent DBE. The 3-year overall survival rate was significantly lower in patients with ( n  = 33), than without ( n  = 30) jejunoileal involvement of NHL confirmed by DBE (49 vs. 92 %, p  < 0.005). Four participants developed aspiration pneumonia, but recovered after treatment with antibiotics.