Induction of peroxisomal enzymes in rat liver by dehydroepiandrosterone sulfate

• Published in: Cancer letters Vol. 111; no. 1; pp. 187 - 190
• Main Authors: Khan, Seher A., Nyce, Jonathan W.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 1997; Elsevier
• Subjects: Animals; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Catalase; Catalase - metabolism; Dehydroepiandrosterone sulfate; Dehydroepiandrosterone Sulfate - pharmacology; Dose-Response Relationship, Drug; Enzyme Induction; Enzymes; General aspects; Induction; Liver; Liver - drug effects; Liver - enzymology; Male; Medical sciences; Microbodies - enzymology; Oxidation-Reduction; Peroxisomal β-oxidation; Rats; Rats, Inbred F344; Tumors; Enzymes; Peroxisomal β-oxidation; Dehydroepiandrosterone sulfate; Catalase; Induction; Liver; Androgen; Rat; Enzyme; Rodentia; Biological activity; Peroxisome proliferator; Carcinogen; In vivo; Vertebrata; Mammalia; Peroxidases; Enzymatic activity; Animal; Peroxisome; Oxidoreductases; Sex steroid hormone
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/S0304-3835(96)04531-4

Male F-344 rats, when treated with either 150 mg/kg or 300 mg/kg body weight of DHEAS for 14 days, produced a dose-dependent increase in liver weight and peroxisomal β-oxidation activity, characteristic of peroxisomal proliferation. Contrary to previous observations in vitro, we also found a significant increase in catalase activity in rat liver with the higher dose of the steroid. Furthermore, the in vivo induction of peroxisomal β-oxidation by DHEAS observed in our study was significantly less than reported in vitro, and also unlike previously reported in vitro results, was approximately equivalent to DHEA administered in vivo.