Intra-abdominal hypertension as a trigger of “gut failure” in SARS-CoV-2 infection: Effect of open abdomen (OA) and negative pressure therapy (NPT) on respiratory and gastrointestinal (GI) function

COVID-19 gastrointestinal manifestations could be attributed to SARS-CoV-2-induced small vessel thrombosis. OA with NPT treatment may have a role in optimization of bowel microcirculation and in the reduction of the endothelial and the systemic cytokine-related damage, improving also respiratory fun...

Full description

Saved in:
Bibliographic Details
Published inMedical hypotheses Vol. 144; p. 109954
Main Authors Di Grezia, Marta, Fransvea, Pietro, Santullo, Francesco, Tirelli, Flavio, Fico, Valeria, Mirco, Paolo, Cozza, Valerio, La Greca, Antonio, Sganga, Gabriele
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.11.2020
Subjects
COVID-19 - complications
Cytokines - physiology
Gastrointestinal Diseases - etiology
Gastrointestinal Diseases - physiopathology
Gastrointestinal Diseases - therapy
Gastrointestinal Tract - blood supply
Gastrointestinal Tract - physiopathology
Humans
Intra-Abdominal Hypertension - etiology
Intra-Abdominal Hypertension - physiopathology
Intra-Abdominal Hypertension - therapy
Microcirculation
Models, Biological
Negative-Pressure Wound Therapy - methods
Open Abdomen Techniques - methods
Pandemics
Online AccessGet full text

Cover

More Information
Summary:COVID-19 gastrointestinal manifestations could be attributed to SARS-CoV-2-induced small vessel thrombosis. OA with NPT treatment may have a role in optimization of bowel microcirculation and in the reduction of the endothelial and the systemic cytokine-related damage, improving also respiratory function.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2020.109954