A NEW METHOD FOR MEASURING IONOPHORETIC ACTIVITY USING A GLASS-CELL APPARATUS EQUIPPED WITH ARTIFICIAL MEMBRANES

• Published in: Chem. Pharm. Bull Vol. 37; no. 5; pp. 1416 - 1418
• Main Authors: KAWANISHI, Hiroyuki, SHIBUYA, Hirotaka, YAMAMOTO, Toshihiro, KOYAMA, Wakuko, OHASHI, Kazuyoshi, KITAGAWA, Isao, NISHINO, Takao
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1989; 公益社団法人日本薬学会; Maruzen
• Subjects: Chemistry; Colloidal state and disperse state; crown ether; Exact sciences and technology; General and physical chemistry; ion-transport activity; ionophore; liquid membrane apparatus; Membranes; merremoside a; merremoside h1; merremoside h_1; oligopeptide-lactone ionophore; Porous materials; resin-glycoside lactone ionophore; theonellapeptolide Id; Specific activity; Ion transfer; Cellulose; Alkali metal Ions; Instrumentation; Crown compound; Liquid membrane; Ionophore; Experimental study; Macrocycle; Alkaline earth metal Ions
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.37.1416

A simple apparatus for measuring the ion-transport activity of a substance has been developed. The apparatus designated W-07 comprises three parts : two glass-cells of aqueous phase sandwiching one teflon cell of organic phase with two artificial membranes in between. Using the apparatus W-07, we have demonstrated the ion-transport activities (for Na+, K+, and Ca++ ions) of an oligopeptide-lactone, and resin-glycosides containing a macrocyclic lactone structure.