Effectiveness of measures to eradicate Staphylococcus aureus carriage in patients with community-associated skin and soft-tissue infections: a randomized trial

• Published in: Infection control and hospital epidemiology Vol. 32; no. 9; p. 872
• Main Authors: Fritz, Stephanie A, Camins, Bernard C, Eisenstein, Kimberly A, Fritz, Joseph M, Epplin, Emma K, Burnham, Carey-Ann, Dukes, Jonathan, Storch, Gregory A
• Format: Journal Article
• Language: English
• Published: United States 01.09.2011
• Subjects: Adolescent; Adult; Anti-Bacterial Agents - administration & dosage; Anti-Infective Agents, Local - administration & dosage; Baths; Carrier State - drug therapy; Child; Child, Preschool; Chlorhexidine - administration & dosage; Combined Modality Therapy; Community-Acquired Infections - drug therapy; Female; Humans; Infant; Male; Mupirocin - administration & dosage; Nose - microbiology; Patient Compliance; Patient Education as Topic; Sodium Hypochlorite - administration & dosage; Soft Tissue Infections - drug therapy; Soft Tissue Infections - therapy; Staphylococcal Skin Infections - drug therapy; Staphylococcal Skin Infections - therapy; Staphylococcus aureus; Treatment Outcome; Young Adult
• ISSN: 1559-6834
• DOI: 10.1086/661285

Despite a paucity of evidence, decolonization measures are prescribed for outpatients with recurrent Staphylococcus aureus skin and soft-tissue infection (SSTI). Compare the effectiveness of 4 regimens for eradicating S. aureus carriage. Open-label, randomized controlled trial. Colonization status and recurrent SSTI were ascertained at 1 and 4 months. Barnes-Jewish and St. Louis Children's Hospitals, St. Louis, Missouri, 2007-2009. Three hundred patients with community-onset SSTI and S. aureus colonization in the nares, axilla, or inguinal folds. Participants were randomized to receive no therapeutic intervention (control subjects) or one of three 5-day regimens: 2% mupirocin ointment applied to the nares twice daily, intranasal mupirocin plus daily 4% chlorhexidine body washes, or intranasal mupirocin plus daily dilute bleach water baths. Among 244 participants with 1-month colonization data, modified intention-to-treat analysis revealed S. aureus eradication in 38% of participants in the education only (control) group, 56% of those in the mupirocin group (P = .03 vs controls), 55% of those in the mupirocin and chlorhexidine group (P = .05), and 63% off those in the mupirocin and bleach group (P = .006). Of 229 participants with 4-month colonization data, eradication rates were 48% in the control group, 56% in the mupirocin only group (P = .40 vs controls), 54% in the mupirocin and chlorhexidine group (P = .51), and 71% in the mupirocin and bleach group (P = .02). At 1 and 4 months, recurrent SSTIs were reported by 20% and 36% of participants, respectively. An inexpensive regimen of dilute bleach baths, intranasal mupirocin, and hygiene education effectively eradicated S. aureus over a 4-month period. High rates of recurrent SSTI suggest that factors other than endogenous colonization are important determinants of infection. Trial registration. ClinicalTrials.gov identifier: NCT00513799.