Protective effect of leaves of Raphinus sativus Linn on experimentally induced gastric ulcers in rats

• Published in: Saudi pharmaceutical journal Vol. 19; no. 3; pp. 171 - 176
• Main Authors: Devaraj, V.C., Gopala Krishna, B., Viswanatha, G.L., Satya Prasad, V., Vinay Babu, S.N.
• Format: Journal Article
• Language: English
• Published: Saudi Arabia Elsevier B.V 01.07.2011
• Subjects: Acetic acid; Collagen content; Gastric ulcer; Original; Raphinus sativus; Regenerated epithelium; Ulcer index; Raphinus sativus; Regenerated epithelium; Gastric ulcer; Acetic acid; Collagen content; Ulcer index
• ISSN: 1319-0164; 2213-7475
• DOI: 10.1016/j.jsps.2011.03.003

Raphinus sativus Linn (Cruciferae) commonly known as ‘Radish’ is a multipurpose herb cultivated in different parts of the world for its edible roots and leaves. The present study was aimed to evaluate the antiulcer activity of leaf extracts of R. sativus Linn on acetic acid induced chronic gastric ulcer and pylorus ligation induced gastric ulcer in rats. The acute oral toxicity study revealed that all the extracts were safe up to 2000 mg/kg per oral dose; hence one-tenth of this dose was selected for evaluation of antiulcer activity. In acetic acid induced gastric ulcer models, the ERS, CRS, EARS and AQRS have offered significant protection against acetic acid induced ulcers when compared to control group. While in pylorus ligation induced ulcer model the ERS, EARS and AQRS showed significant protection by decreasing the ulcer index, total acidity and free acidity. In conclusion the leaf extracts of R. sativus Linn are found to possess antiulcer property in the experimental animal models of gastric ulcers, which is consistent with the literature report in the folk medicine.