Mechanism of arsenic carcinogenesis: an integrated approach

Epidemiological evidence shows an association between inorganic arsenic in drinking water and increased risk of skin, lung and bladder cancers. The lack of animal models has hindered mechanistic studies of arsenic carcinogenesis in the past, but some promising new models for these cancers are now av...

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Bibliographic Details
Published inMutation research Vol. 533; no. 1-2; p. 37
Main Author Rossman, Toby G
Format Journal Article
LanguageEnglish
Published Netherlands 10.12.2003
Subjects
Animals
Arsenic - toxicity
Arsenites - toxicity
Carcinogens - toxicity
Cell Division
Chromosomal Instability
DNA Damage
DNA Methylation
Environmental Exposure
Gene Amplification
Humans
Mice
Models, Animal
Neoplasms - chemically induced
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Summary:Epidemiological evidence shows an association between inorganic arsenic in drinking water and increased risk of skin, lung and bladder cancers. The lack of animal models has hindered mechanistic studies of arsenic carcinogenesis in the past, but some promising new models for these cancers are now available. The various forms of arsenic to which humans are exposed, either directly or via metabolism of inorganic arsenic to various methylated forms, further complicate the issue of mechanism, since these compounds can have different effects, both genotoxic and non-genotoxic. This review will try to integrate all of these issues, with a strong bias toward effects that are produced by environmentally relevant arsenic concentrations.
ISSN:0027-5107
DOI:10.1016/j.mrfmmm.2003.07.009