The fetal rat gubernaculum contains higher levels of androgen receptor than does the postnatal gubernaculum

The androgen receptor of the rat gubernaculum was measured by a sensitive immunoblotting technique from day 19 of fetal development to day 20 of postnatal development. In relative terms (densitometric units/microgram. protein), it was found that the amount of the gubernacular androgen receptor decre...

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Bibliographic Details
Published inThe Journal of urology Vol. 150; no. 5 Pt 1; p. 1564
Main Authors Bentvelsen, F M, George, F W
Format Journal Article
LanguageEnglish
Published United States 01.11.1993
Subjects
Age Factors
Animals
Animals, Newborn
Fetus - embryology
Gestational Age
Male
Rats
Rats, Sprague-Dawley
Receptors, Androgen - analysis
Receptors, Androgen - physiology
Testis - embryology
Testis - growth & development
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Summary:The androgen receptor of the rat gubernaculum was measured by a sensitive immunoblotting technique from day 19 of fetal development to day 20 of postnatal development. In relative terms (densitometric units/microgram. protein), it was found that the amount of the gubernacular androgen receptor decreased dramatically from fetal to postnatal development, coincident with the transition of the gubernaculum from a tissue primarily composed of undifferentiated mesenchymal cells in the fetus to a tissue that is primarily made up of muscle during postnatal development. We conclude that the undifferentiated mesenchyme of the fetal gubernaculum is a primary target of androgen action.
ISSN:0022-5347
DOI:10.1016/S0022-5347(17)35842-1