The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management

(HP) is a facultative anaerobic bacterium. HP is a normal flora having immuno-modulating properties. This bacterium is an example of a microorganism inducing gastric cancer. Its carcinogenicity depends on bacteria-host related factors. The proper understanding of the biology of HP inducing gastric c...

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Published inFrontiers in oncology Vol. 9; p. 75
Main Authors Alfarouk, Khalid O, Bashir, Adil H H, Aljarbou, Ahmed N, Ramadan, AbdelRahman M, Muddathir, Abdel Khalig, AlHoufie, Sari T S, Hifny, Abdelhamid, Elhassan, Gamal O, Ibrahim, Muntaser E, Alqahtani, Saad S, AlSharari, Shakir D, Supuran, Claudiu T, Rauch, Cyril, Cardone, Rosa Angela, Reshkin, Stephan J, Fais, Stefano, Harguindey, Salvador
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 22.02.2019
Subjects
gastric cancer
Helicobacter pylori
inflammation
Oncology
pharmacology
pH
Helicobacter pylori
gastric cancer
inflammation
pharmacology
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Summary:(HP) is a facultative anaerobic bacterium. HP is a normal flora having immuno-modulating properties. This bacterium is an example of a microorganism inducing gastric cancer. Its carcinogenicity depends on bacteria-host related factors. The proper understanding of the biology of HP inducing gastric cancer offers the potential strategy in the managing of HP rather than eradicating it. In this article, we try to summarize the biology of HP-induced gastric cancer and discuss the current pharmacological approach to treat and prevent its carcinogenicity.
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Reviewed by: Amit Gupta, All India Institute of Medical Sciences, Rishikesh, India; Cristiana Laudi, Istituto di Candiolo (IRCCS), Italy
This article was submitted to Gastrointestinal Cancers, a section of the journal Frontiers in Oncology
Edited by: Tiziana Venesio, Institute for Cancer Research and Treatment (IRCC), Italy
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2019.00075