Chemiluminescence flow-injection analysis of captopril applying a sensitized rhodamine 6G method

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 14; no. 8; pp. 939 - 945
• Main Authors: Zhang, Z.D., Baeyens, W.R.G., Zhang, X.R., Van der Weken, G.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 01.06.1996; Elsevier Science
• Subjects: Analysis; Biological and medical sciences; Captopril; Captopril - analysis; Ce(IV); Cerium; Chemiluminescence; Coloring Agents; Flow Injection Analysis - methods; Flow-injection analysis; General pharmacology; Luminescent Measurements; Medical sciences; Pharmacology. Drug treatments; Rhodamine 6G; Rhodamines; Sulfuric Acids; Tablets - analysis; Ce(IV); Chemiluminescence; Captopril; Rhodamine 6G; Flow-injection analysis; Dosage form; Antihypertensive agent; Cerium IV; Photochemical reaction; ACE inhibitor; Quantitative analysis; Flow injection
• ISSN: 0731-7085; 1873-264X
• DOI: 10.1016/S0731-7085(95)01733-X

A flow-injection analysis with chemiluminescence detection is described for the determination of captopril based on the photochemical reaction with cerium(IV) in sulphuric acid medium yielding a strong chemiluminescent signal which can be sensitized by some fluorescers. The proposed procedure has a linear application range of 1 × 10 −6–2 × 10 −4 M ( r = 0.997) with a detection limit of 2 × 10 −7 M, an RSD of 2.8% at 1 × 10 −6 M captopril, and a sample measurement frequency of 500 h −1. The method was used for the simple and rapid determination of captopril in a pharmaceutical preparation.