Calcineurin: A star is reborn

The protein phosphatase calcineurin has long been familiar to the calcium community, but the definition of its physiological substrates has been far from complete. A new study rectifies this deficiency and sets the stage for new insights into the role of calcineurin in diverse cellular processes.

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Bibliographic Details
Published inCell calcium (Edinburgh) Vol. 94; p. 102324
Main Authors Li, Huiming, Hogan, Patrick G.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.03.2021
Subjects
Animals
Calcineurin
Calcineurin - chemistry
Calcineurin - metabolism
Docking motif
Humans
LxVP
NFATC Transcription Factors - metabolism
Phage display
PxIxIT
Signal Transduction
SLiM
Substrate
Substrate Specificity
Substrate
LxVP
Phage display
PxIxIT
Docking motif
Calcineurin
SLiM
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Summary:The protein phosphatase calcineurin has long been familiar to the calcium community, but the definition of its physiological substrates has been far from complete. A new study rectifies this deficiency and sets the stage for new insights into the role of calcineurin in diverse cellular processes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Present address: Acceleron Pharma, Cambridge, MA 02139, USA.
ISSN:0143-4160
1532-1991
DOI:10.1016/j.ceca.2020.102324