Impact of spinal kyphosis on gastroesophageal reflux disease symptoms in patients with osteoporosis

• Published in: Osteoporosis international Vol. 20; no. 7; pp. 1193 - 1198
• Main Authors: Miyakoshi, N, Kasukawa, Y, Sasaki, H, Kamo, K, Shimada, Y
• Format: Journal Article
• Language: English
• Published: London London : Springer-Verlag 01.07.2009; Springer-Verlag; Springer; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Biological and medical sciences; Bone Density; Bone Density Conservation Agents - administration & dosage; Bone diseases; Diphosphonates - administration & dosage; Diseases of the osteoarticular system; Diseases of the spine; Endocrinology; Esophagus; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gastroesophageal reflux; Gastroesophageal Reflux - etiology; Gastroesophageal reflux disease (GERD); Humans; Kyphosis; Kyphosis - complications; lumbar spine; Lumbar Vertebrae - injuries; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Older people; Original Article; Orthopedics; osteoporosis; Osteoporosis - complications; Osteoporosis - drug therapy; Osteoporosis. Osteomalacia. Paget disease; Other diseases. Semiology; Questionnaires; Rheumatology; Risk Factors; Spinal Fractures - complications; Spine; Thoracic Vertebrae - injuries; Osteoporosis; Kyphosis; Questionnaire; Lumbar spine; Gastroesophageal reflux disease (GERD); Human; Gastroesophageal reflux; Deformation; Esophageal disease; Diseases of the osteoarticular system; Rheumatology; Spine disease; Symptomatology; Dorsal spine; Digestive diseases
• ISSN: 0937-941X; 1433-2965
• DOI: 10.1007/s00198-008-0777-x

Summary Spinal kyphosis has been speculated to participate in the increased frequency of gastroesophageal reflux disease (GERD) in patients with osteoporosis. The present study provides further evidence that increases in lumbar kyphosis and number of vertebral fractures represent very important risk factors for GERD in patients with osteoporosis. Introduction Osteoporosis and spinal kyphosis have been speculated to participate in the increased frequency of gastroesophageal reflux disease (GERD). The present study examined whether GERD in patients with osteoporosis is affected by spinal factors including spinal kyphosis in the presence of oral pharmacotherapies. Methods Subjects comprised 112 patients with osteoporosis (mean age, 78 years) who responded to the Frequency Scale for Symptoms of GERD (FSSG) questionnaire, regardless of complaints. Relationships between total FSSG score and number of vertebral fractures, angles of kyphosis, use of bisphosphonates and nonsteroidal anti-inflammatory drugs (NSAIDs), and total number of oral medicines per day were evaluated. Logistic regression identified factors associated with GERD. Results Bisphosphonates and NSAIDs did not affect total FSSG score. Total FSSG score showed significant positive correlations with total number of medicines (r = 0.283, p = 0.0025), angle of lumbar kyphosis (r = 0.576, p = 0.0001), and numbers of thoracic vertebral fractures (r = 0.214, p = 0.0232) and lumbar vertebral fractures (r = 0.471, p < 0.0001). Angle of lumbar kyphosis and number of lumbar vertebral fractures were identified by multivariate analysis as indices affecting the presence of GERD. Conclusion Increases in angle of lumbar kyphosis and number of lumbar vertebral fractures may5 represent very important risk factors for GERD in osteoporotic patients.