Oily contrast medium as a therapeutic agent for infertility because of mild endometriosis

• Published in: Fertility and sterility Vol. 59; no. 4; pp. 907 - 911
• Main Authors: Sawatari, Yoshiharu, Horii, Takahisa, Hoshiai, Hiroshi
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.1993; Elsevier Science
• Subjects: Animals; Biological and medical sciences; Cells, Cultured; danazol; Danazol - therapeutic use; Dinoprost - analysis; Dinoprostone - analysis; Endometriosis; Endometriosis - complications; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; infertility; Infertility, Female - drug therapy; Infertility, Female - etiology; interleukin; Interleukin-1 - analysis; intraperitoneal macrophage; Iodized Oil - therapeutic use; Macrophages - drug effects; Macrophages - physiology; Male; Medical sciences; Mice; Mice, Inbred ICR; Non tumoral diseases; oily contrast medium; Peritoneal Cavity - cytology; Picibanil - pharmacology; Pregnancy; prostaglandin; intraperitoneal macrophage; prostaglandin; danazol; Endometriosis; infertility; oily contrast medium; interleukin; Prostaglandin; Arachidonic acid derivatives; Interleukin; Cytokine; Female sterility; Oily solution; In vitro; Female genital diseases; In vivo; Treatment; Animal; Uterine diseases; Contrast media; Peritoneum; Macrophage
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/S0015-0282(16)55880-4

To investigate the utility of using oily contrast medium (Lipiodol; Kodama, Tokyo, Japan) to treat infertility because of mild endometriosis. Macrophages in the peritoneal cavity of ICR mice (Japan SLC, Shizuoka, Japan) were induced by administering OK-432 to simulate the condition of the peritoneal cavity of patients with mild endometriosis, and the pregnancy rate was examined after administration of Lipiodol and/or danazol (Bonzol; Tokyo Tanabe, Tokyo, Japan). Interleukin-1β (IL-1β), prostaglandin (PG)F2α (PGF2α), and PGE2 levels in the supernatant were measured after incubating macrophages of mice with Lipiodol and/or danazol. Pregnancy rate (PR) and IL-1β, PGF2α, and PGE2 levels. The PR of the Lipiodol group was significantly increased compared with that in control mice. Prostaglandin F2α level in the supernatant was significantly increased, whereas that of IL-lβ was reduced after incubation with Lipiodol. Lipiodol may elevate PGF2α level and reduce IL-1β level in the peritoneal cavity, and this drug may increase the PR of ICR mice.