Distinct globus pallidus circuits regulate motor and cognitive functions

A recent article by Lilascharoen et al. identified two distinct pathways in the globus pallidus (GPe) that are associated with discrete behaviors. Dysfunctions in these pathways were shown to underlie Parkinsonian motor and cognitive deficits in mice, and selective manipulation of these circuits res...

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Bibliographic Details
Published inTrends in neurosciences (Regular ed.) Vol. 44; no. 8; pp. 597 - 599
Main Authors Aristieta, Asier, Gittis, Aryn
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2021
Subjects
Animals
Cognition
cognitive function
external segment of the globus pallidus (GPe)
Globus Pallidus
locomotion
Mice
Neurons
Parkinson's disease
parvalbumin
reversal learning
cognitive function
reversal learning
Parkinson's disease
external segment of the globus pallidus (GPe)
parvalbumin
locomotion
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Summary:A recent article by Lilascharoen et al. identified two distinct pathways in the globus pallidus (GPe) that are associated with discrete behaviors. Dysfunctions in these pathways were shown to underlie Parkinsonian motor and cognitive deficits in mice, and selective manipulation of these circuits rescued locomotor deficits and improved behavioral flexibility.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Commentary-3
content type line 23
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2021.06.001