Distinct Longitudinal Changes in Immunoglobulin G N-Glycosylation Associate with Therapy Response in Chronic Inflammatory Diseases

• Published in: International journal of molecular sciences Vol. 23; no. 15; p. 8473
• Main Authors: Štambuk, Jerko, Vučković, Frano, Habazin, Siniša, Hanić, Maja, Novokmet, Mislav, Nikolaus, Susanna, Tran, Florian, Schreiber, Stefan, Franke, Andre, Rosenstiel, Philip, Lauc, Gordan, Aden, Konrad, Pezer, Marija
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.08.2022; MDPI
• Subjects: Autoimmune diseases; Azathioprine; Biological products; chronic inflammatory diseases; Crohns disease; Cytotoxicity; Glycosylation; IgG antibody; IgG glycosylation; Immunoglobulin G; Immunoglobulins; Immunosuppressive agents; Immunotherapy; Inflammation; Inflammatory bowel disease; Inflammatory diseases; Infliximab; Lupus; Monoclonal antibodies; Patients; personalized medicine; Remission; response; Rheumatoid arthritis; Tumor necrosis factor-α

Immunosuppressants and biologicals are widely used therapeutics for various chronic inflammatory diseases (CID). To gain more detailed insight into their downstream effects, we examined their impact on serum immunoglobulin G (IgG) glycosylation. We analyzed IgG subclass-specific fragment crystalliza...