Nitrosative stress and potassium channel-mediated neuronal apoptosis: is zinc the link?

Nitrosative stress has been implicated in a large number of neurological disorders. The molecular mechanisms underlying the neuronal injury associated with this stimulus, however, are not clearly understood. Emerging evidence suggests that the liberation of intracellular zinc as well as over-activat...

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Bibliographic Details
Published inPflügers Archiv Vol. 448; no. 3; pp. 296 - 303
Main Authors Pal, Sumon, He, Kai, Aizenman, Elias
Format Journal Article
LanguageEnglish
Published Germany Springer Nature B.V 01.06.2004
Subjects
Animals
Apoptosis
Apoptosis - drug effects
Apoptosis - physiology
Humans
Neurology
Neurons - drug effects
Neurons - metabolism
Neurons - pathology
Oxidative Stress - physiology
Peroxynitrous Acid - adverse effects
Peroxynitrous Acid - metabolism
Potassium Channels, Voltage-Gated - drug effects
Potassium Channels, Voltage-Gated - metabolism
Tyrosine - adverse effects
Tyrosine - analogs & derivatives
Tyrosine - metabolism
Zinc - metabolism
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Summary:Nitrosative stress has been implicated in a large number of neurological disorders. The molecular mechanisms underlying the neuronal injury associated with this stimulus, however, are not clearly understood. Emerging evidence suggests that the liberation of intracellular zinc as well as over-activation of potassium channels may be two important components of nitrosative stress-induced neuronal death.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-004-1256-7