Isoprinosine does not influence the natural history of herpes zoster or postherpetic neuralgia

In a double-blind randomised trial, 38 elderly patients with acute herpes zoster received either isoprinosine (IP) or placebo. IP neither shortened the acute phase of herpes zoster nor prevented postherpetic neuralgia. Transient asymptomatic hyperuricaemia affected one third of IP treated patients....

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Bibliographic Details
Published inScandinavian journal of infectious diseases Vol. 21; no. 1; p. 15
Main Authors Payne, C M, Menday, A P, Rogers, T, Staughton, R C
Format Journal Article
LanguageEnglish
Published England 1989
Subjects
Aged
Aged, 80 and over
Clinical Trials as Topic
Double-Blind Method
Female
Herpes Zoster - complications
Herpes Zoster - drug therapy
Humans
Inosine - analogs & derivatives
Inosine Pranobex - pharmacology
Male
Middle Aged
Neuralgia - etiology
Neuralgia - prevention & control
Random Allocation
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Summary:In a double-blind randomised trial, 38 elderly patients with acute herpes zoster received either isoprinosine (IP) or placebo. IP neither shortened the acute phase of herpes zoster nor prevented postherpetic neuralgia. Transient asymptomatic hyperuricaemia affected one third of IP treated patients. Shortcomings in study design and misleading interpretation of results are common in previously published clinical trials of herpes zoster and postherpetic neuralgia. Guidelines for future studies are proposed.
ISSN:0036-5548
1651-1980
DOI:10.3109/00365548909035675