How Machine Perfusion Ameliorates Hepatic Ischaemia Reperfusion Injury

• Published in: International journal of molecular sciences Vol. 22; no. 14; p. 7523
• Main Authors: Clarke, George, Mergental, Hynek, Hann, Angus, Perera, M. Thamara P. R., Afford, Simon C., Mirza, Darius F.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 14.07.2021; MDPI
• Subjects: Acids; Blood flow; Cold; Cytokines; Cytotoxicity; Dehydrogenases; Endothelium; hypothermic; Hypoxia; Inflammation; ischaemia reperfusion injury; Ischemia; Lipids; liver transplant; Liver transplants; machine perfusion; Metabolism; Musculoskeletal system; Nitric oxide; normothermic; Organs; Pathophysiology; Perfusion; Reperfusion; Review; Sodium; Transplantation; Tumor necrosis factor-TNF
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms22147523

The increasing disparity between the number of patients listed for transplantation and the number of suitable organs has led to the increasing use of extended criteria donors (ECDs). ECDs are at increased risk of developing ischaemia reperfusion injury and greater risk of post-transplant complications. Ischaemia reperfusion injury is a major complication of organ transplantation defined as the inflammatory changes seen following the disruption and restoration of blood flow to an organ—it is a multifactorial process with the potential to cause both local and systemic organ failure. The utilisation of machine perfusion under normothermic (37 degrees Celsius) and hypothermic (4–10 degrees Celsius) has proven to be a significant advancement in organ preservation and restoration. One of the key benefits is its ability to optimise suboptimal organs for successful transplantation. This review is focused on examining ischaemia reperfusion injury and how machine perfusion ameliorates the graft’s response to this.