The 3′-5′ exonucleases

Over the past few years, several new 3' 5' exonucleases have been identified. In vitro studies of these enzymes have uncovered much about their potential functions in vivo, and certain organisms with a defect in 3' 5' exonucleases have an increased susceptibility to cancer, espec...

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Bibliographic Details
Published inNature reviews. Molecular cell biology Vol. 3; no. 5; pp. 364 - 376
Main Authors Hübscher, Ulrich, Shevelev, Igor V
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.05.2002
Subjects
Amino Acid Sequence
Animals
DNA Helicases - physiology
DNA Polymerase III - physiology
DNA Repair - physiology
DNA Replication - physiology
Exodeoxyribonuclease V
Exodeoxyribonucleases - chemistry
Exodeoxyribonucleases - physiology
Humans
Molecular Sequence Data
Phosphoproteins
Protein Structure, Tertiary
Recombination, Genetic
RecQ Helicases
Sequence Alignment
Werner Syndrome Helicase
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Summary:Over the past few years, several new 3' 5' exonucleases have been identified. In vitro studies of these enzymes have uncovered much about their potential functions in vivo, and certain organisms with a defect in 3' 5' exonucleases have an increased susceptibility to cancer, especially under conditions of stress. Here, we look at not only the newly discovered enzymes, but also at the roles of other 3' 5' exonucleases in the quality control of DNA synthesis, where they act as proofreading exonucleases for DNA polymerases during DNA replication, repair and recombination.
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ISSN:1471-0072
1471-0080
DOI:10.1038/nrm804