Concentrations of cloxacillin, dicloxacillin and flucloxacillin in dental alveolar serum and mandibular bone

• Published in: International journal of oral surgery Vol. 11; no. 1; pp. 40 - 43
• Main Authors: Köndell, P.Å., Nord, C.E., Nordenram, Å.
• Format: Journal Article
• Language: English
• Published: Denmark Elsevier Inc 01.01.1982
• Subjects: Administration, Oral; Adult; bone, mandibular; Cloxacillin - analogs & derivatives; Cloxacillin - analysis; Cloxacillin - blood; cloxacillin, dicloxacillin, flucloxacillin concentrations; Dentistry; Dicloxacillin - analysis; Dicloxacillin - blood; Female; Floxacillin - analysis; Floxacillin - blood; Humans; Male; Mandible - analysis; Molar, Third - surgery; serum, dental alveolar; Time Factors; bone, mandibular; serum, dental alveolar; cloxacillin, dicloxacillin, flucloxacillin concentrations
• ISSN: 0300-9785
• DOI: 10.1016/S0300-9785(82)80047-1

Deep infections caused by staphylococci are serious complications after oral surgery. Intensive antibiotic treatment is always necessary in these infections. Isoxazolylpenicillins are often used. Levels of three isoxazolylpenicil-lins, namely, cloxacillin, dicloxacillin and flucloxacillin, were measured in serum, dental alveolar serum and mandibular bone in 60 patients undergoing surgical removal of impacted third molars after a single dose of 500 mg. The systemic serum concentrations were higher than the dental alveolar serum concentrations in most patients. The maximum concentration in the alveolar serum was 3.8–6.4 μ/ml for cloxacillin, 6.0–15.0 μ/ml for dicloxacillin and 10.0–15.0 μ/ml for flucloxacillin. The concentration in mandibular bone was 2.0 ±0.4 μ/g for cloxacillin, 2.0 ±0.5 μ/g for dicloxacillin and 2.0 ±0.5 μ/g for flucloxacillin.