Understanding the kidney one cell at a time

A revolution in cellular measurement technology is underway. Whereas prior studies have been able to analyze only the averaged outputs from renal tissue, we now can accurately monitor genome-wide gene expression, regulation, function, cellular history, and cellular interactions in thousands of indiv...

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Published inKidney international Vol. 96; no. 4; pp. 862 - 870
Main Authors Park, Jihwan, Liu, Chang (Linda), Kim, Junhyong, Susztak, Katalin
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.2019
Subjects
epigenome
kidney disease
RNA-seq
single cell
kidney disease
epigenome
single cell
RNA-seq
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Summary:A revolution in cellular measurement technology is underway. Whereas prior studies have been able to analyze only the averaged outputs from renal tissue, we now can accurately monitor genome-wide gene expression, regulation, function, cellular history, and cellular interactions in thousands of individual cells in a single experiment. These methods are key drivers in changing our previous morphotype-based organ and disease descriptions to unbiased genomic definitions and therefore improving our understanding of kidney development, homeostasis, and disease.
Bibliography:ObjectType-Article-1
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ISSN:0085-2538
1523-1755
DOI:10.1016/j.kint.2019.03.035