The role of Toll-like receptors and Nod proteins in bacterial infection

• Published in: Molecular immunology Vol. 41; no. 11; pp. 1099 - 1108
• Main Authors: Philpott, Dana J., Girardin, Stephen E.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2004
• Subjects: Adaptor Proteins, Signal Transducing - immunology; Adaptor Proteins, Signal Transducing - physiology; Animals; Bacteria; Bacterial Infections - immunology; Drosophila Proteins - immunology; Drosophila Proteins - physiology; Gram-Negative Bacterial Infections - immunology; Innate immunity; Intracellular Signaling Peptides and Proteins - immunology; Intracellular Signaling Peptides and Proteins - physiology; Kinesin; Membrane Glycoproteins - immunology; Membrane Glycoproteins - physiology; Mice; Microbial infection; Microtubule Proteins - immunology; Microtubule Proteins - physiology; Nod1; Nod1 Signaling Adaptor Protein; Nod2; Nod2 Signaling Adaptor Protein; Receptors, Cell Surface - immunology; Receptors, Cell Surface - physiology; Toll-Like Receptors; Toll-like receptors; Innate immunity; Nod2; Nod1; Microbial infection
• ISSN: 0161-5890; 1872-9142
• DOI: 10.1016/j.molimm.2004.06.012

Our understanding of innate immunity in mammals has greatly expanded following the discovery of the family of membrane-bound receptors, called the Toll-like receptors (TLRs). More recently, the nucleotide-binding oligomerisation domain (Nod) molecules, Nod1 and Nod2, which are cytoplasmic surveillance proteins, have also been shown to be involved in the innate immune response. These two classes of detection molecules, classified as “pattern recognition receptors” (PRRs), detect microbial ligands in order to initiate a defense response to fight infectious disease. These microbial ligands or “pathogen-associated molecular patterns” (PAMPs), detected by TLRs and Nods are often structural components of the microorganism that are not subject to much variation. These include such factors as lipopolysaccharide (LPS) and peptidoglycan from the cell walls of bacteria. In order to understand the role of TLRs and Nod proteins in infectious disease in vivo it is important to define the site of interaction between PRRs and PAMPS. Additionally, the challenge of mice deficient in the various PRRs in natural infection models will help to decipher the contribution of these molecules not only in the innate immune response against pathogen infection but also how these proteins may instruct the adaptive immune response in order to have a tailored immune response against a particular microbe.