Use of Inclusion Complex of Cyclodextrin with Ambenonium to Improve the Treatment of Anticholinesterase Poisoning

The complex of ambenonium with methyl-β-cyclodextrin injected intramuscularly to rats caused more pronounced inhibition of acetylcholinesterase in erythrocyte and brain than free drug. The use of this complex as part of combined therapy significantly reduces mortality in animals during experimental...

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Published inBulletin of experimental biology and medicine Vol. 155; no. 2; pp. 218 - 220
Main Authors Yudin, M. A., Ivanov, I. M., Nikiforov, A. S., Kornyukhina, T. M., Tyunin, M. A.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.06.2013
Springer
Springer Nature B.V
Subjects
Acetylcholinesterase - metabolism
Ambenonium Chloride - therapeutic use
Animals
beta-Cyclodextrins - therapeutic use
Biomedical and Life Sciences
Biomedicine
Brain - drug effects
Brain - enzymology
Brain - metabolism
Cell Biology
Cholinesterase Inhibitors - poisoning
Cholinesterase Inhibitors - toxicity
Cyclodextrins
Drug Combinations
Erythrocytes - drug effects
Erythrocytes - enzymology
Erythrocytes - metabolism
Internal Medicine
Laboratory Medicine
Male
Pathology
Poisoning
Rats
anticholinesterase poisoning
blood–brain barrier
ambenonium
cyclodextrin
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Summary:The complex of ambenonium with methyl-β-cyclodextrin injected intramuscularly to rats caused more pronounced inhibition of acetylcholinesterase in erythrocyte and brain than free drug. The use of this complex as part of combined therapy significantly reduces mortality in animals during experimental anticholinesterase poisoning in comparison with the controls.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2117-1