Coagulation inhibitors in alcoholic liver cirrhosis

• Published in: Alcohol (Fayetteville, N.Y.) Vol. 15; no. 1; pp. 19 - 23
• Main Authors: Raya-Sánchez, J.M., González-Reimers, E., Rodríguez-Martín, J.M., Santolaria-Fernández, F., Molina-Pérez, M., Rodríguez-Moreno, F., Martínez-Riera, A.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 1998; Elsevier Science
• Subjects: Adult; Aged; Alcoholism and acute alcohol poisoning; Alcoholism cirrhosis; Antithrombin III; Antithrombin III - metabolism; Biological and medical sciences; Blood Coagulation Factor Inhibitors - blood; Female; Humans; Liver Cirrhosis, Alcoholic - blood; Liver Cirrhosis, Alcoholic - classification; Male; Medical sciences; Middle Aged; PAI; Plasminogen Activator Inhibitor 1 - metabolism; Protein C; Protein C - metabolism; Protein S; Protein S - metabolism; t-PA; Thrombomodulin; Thrombomodulin - blood; Tissue Plasminogen Activator - metabolism; Toxicology; Antithrombin III; PAI; Protein S; Protein C; Thrombomodulin; Alcoholism cirrhosis; t-PA; Human; Blood coagulation; Serine endopeptidases; Enzyme; Alcoholism; Enzyme inhibitor; Hepatic disease; t-Plasminogen activator; Peptidases; Cirrhosis; Digestive diseases; Hydrolases; Inhibitor; Coagulopathy
• ISSN: 0741-8329; 1873-6823
• DOI: 10.1016/S0741-8329(97)00082-7

In the present study we have analyzed the relationship between coagulation inhibitors (antithrombin III, protein C and S, thrombomodulin), liver function impairment, and plasma activity of the endothelium-derived proteins plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) in 27 alcoholic cirrhotic patients and 25 controls. Cirrhotics showed decreased values of all the mentioned parameters except for thrombomodulin, PAI-1, and t-PA. Thrombomodulin and t-PA levels were higher in cirrhotics. No relationship was observed between thrombomodulin and t-PA or PAI-1. Protein C and antithrombin III levels were significantly lower in Child's C patients, whereas no correlation was found between t-PA and thrombomodulin and hepatic function derangement. PAI-1 activity was normal in our patients.