Long non‑coding RNAs in small cell lung cancer: A potential opening to combat the disease (Review)

• Published in: Oncology reports Vol. 40; no. 4; pp. 1831 - 1842
• Main Authors: Li, Tian-Tian, He, Rong-Quan, Ma, Jie, Li, Zu-Yun, Hu, Xiao-Hua, Chen, Gang
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.10.2018; Spandidos Publications UK Ltd
• Subjects: Animals; Apoptosis; Breast cancer; Care and treatment; Cell adhesion & migration; Cell cycle; Cell growth; Chemotherapy; Colorectal cancer; Deoxyribonucleic acid; Development and progression; DNA; DNA damage; DNA methylation; Gene expression; Gene Expression Regulation, Neoplastic; Genetic aspects; Genomes; Health aspects; Humans; Kinases; Liver cancer; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - therapy; Lymphatic system; Lymphoma; Medical prognosis; Metastasis; Mutation; Pancreatic cancer; Prostate cancer; Protein synthesis; Proteins; RNA; RNA, Long Noncoding - genetics; Small cell lung cancer; Small Cell Lung Carcinoma - genetics; Small Cell Lung Carcinoma - therapy; Telomerase; Thyroid gland
• ISSN: 1021-335X; 1791-2431
• DOI: 10.3892/or.2018.6635

Lung cancer is the top cause of cancer‑associated mortality in men and women worldwide. Small cell lung cancer (SCLC) is a subtype that constitutes ~15% of all lung cancer cases. Long non‑coding RNAs (lncRNAs), possessing no or limited protein‑coding ability, have gained extensive attention as a potentially promising avenue by which to investigate the biological regulation of human cancer. lncRNAs can modulate gene expression at the transcriptional, post‑transcriptional and epigenetic levels. The current review highlights the developing clinical implications and functional roles of lncRNAs in SCLC, and provides directions for their future utilization in the diagnosis and treatment of SCLC.