Echocardiographic Myocardial Work: A Novel Method to Assess Left Ventricular Function in Patients with Coronary Artery Disease and Diabetes Mellitus

• Published in: Medicina (Kaunas, Lithuania) Vol. 60; no. 2; p. 199
• Main Authors: Frișan, Alexandra-Cătălina, Mornoș, Cristian, Lazăr, Mihai-Andrei, Șoșdean, Raluca, Crișan, Simina, Ionac, Ioana, Luca, Constantin-Tudor
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2024
• Subjects: Age; Automation; Blood pressure; Cardiovascular disease; Care and treatment; Clinical medicine; Comparative analysis; coronary artery disease; Coronary Artery Disease - complications; Coronary Artery Disease - diagnostic imaging; Coronary heart disease; Coronary vessels; Diabetes; Diabetes Mellitus; Diabetics; Diagnosis; Echocardiography; Energy consumption; global longitudinal strain; Heart rate; Humans; Ischemia; left ventricular ejection fraction; Medical research; Medicine, Experimental; Metabolism; Methods; Mortality; myocardial dysfunction; myocardial work; Patients; pressure-strain-loop; Stroke Volume; Type 2 diabetes; Vein & artery diseases; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - etiology; Ventricular Function, Left; Womens health; coronary artery disease; global longitudinal strain; pressure-strain-loop; myocardial dysfunction; myocardial work; diabetes mellitus; left ventricular ejection fraction
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina60020199

Myocardial ischemia caused by coronary artery disease (CAD) and the presence of metabolic abnormalities and microvascular impairments detected in patients with diabetes mellitus (DM) are a common cause of left ventricular (LV) dysfunction. Transthoracic echocardiography is the most-used, non-invasive imaging method for the assessment of myocardial contractility. The accurate evaluation of LV function is crucial for identifying patients who are at high risk or may have worse outcomes. Myocardial work (MW) is emerging as an alternative tool for the evaluation of LV systolic function, providing additional information on cardiac performance when compared to conventional parameters such as left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) because it incorporates deformation and load into its analysis. The potential of MW in various conditions is promising and it has gained increased attention. However, larger studies are necessary to further investigate its role and application before giving an answer to the question of whether it can have widespread implementation into clinical practice. The aim of this review is to summarize the actual knowledge of MW for the analysis of LV dysfunction caused by myocardial ischemia and hyperglycemia.