Lifetime Care of Duchenne Muscular Dystrophy

Individuals with Duchenne muscular dystrophy (DMD) have evolving sleep and respiratory pathophysiology over their lifetimes. Across the lifespan of DMD, various sleep-related breathing disorders (SRBD) have been described, including obstructive sleep apnea, central sleep apnea, and nocturnal hypoven...

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Bibliographic Details
Published inSleep medicine clinics Vol. 15; no. 4; p. 485
Main Authors MacKintosh, Erin W, Chen, Maida L, Benditt, Joshua O
Format Journal Article
LanguageEnglish
Published United States 01.12.2020
Subjects
Disease Progression
Humans
Muscular Dystrophy, Duchenne - complications
Muscular Dystrophy, Duchenne - therapy
Respiratory failure
Duchenne muscular dystrophy
Insomnia hypoventilation
Neuromuscular disease
Noninvasive ventilation
Obstructive sleep apnea
Polysomnogram
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Summary:Individuals with Duchenne muscular dystrophy (DMD) have evolving sleep and respiratory pathophysiology over their lifetimes. Across the lifespan of DMD, various sleep-related breathing disorders (SRBD) have been described, including obstructive sleep apnea, central sleep apnea, and nocturnal hypoventilation. In addition to SRBD, individuals with DMD can be affected by insomnia, chronic pain and other factors interfering with sleep quality, and daytime somnolence. The natural progression of DMD pathophysiology has changed with the introduction of therapies for downstream pathologic pathways and will continue to evolve with the development of therapies that target function and expression of dystrophin.
ISSN:1556-4088
DOI:10.1016/j.jsmc.2020.08.011