Microbial N-demethylation: biotransformation and recovery of a drug metabolite
A total of 39 microbes were screened for the ability to selectively N-demethylate (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)aminopyrimidin-5-yl)-3,5-dihydroxy-hept-6-enoic acid (I), a potential drug for lowering blood cholesterol levels. Two Streptomyces sp...
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Published in | Biotechnology and applied biochemistry Vol. 53; no. Pt 2; p. 133 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.06.2009
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Subjects | |
Online Access | Get more information |
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Summary: | A total of 39 microbes were screened for the ability to selectively N-demethylate (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)aminopyrimidin-5-yl)-3,5-dihydroxy-hept-6-enoic acid (I), a potential drug for lowering blood cholesterol levels. Two Streptomyces species were found to carry out the desired N-demethylation. Bioconversion by Streptomyces griseus A.T.C.C. 13273 and product recovery were scaled up to the multi-gram level. |
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ISSN: | 1470-8744 |
DOI: | 10.1042/BA20080079 |