Benefits and risks of mitomycin use in the traumatized tracheal mucosa

• Published in: Otolaryngology-head and neck surgery Vol. 136; no. 3; p. 459
• Main Authors: Roh, Jong-Lyel, Kim, Dong Hyun, Rha, Ki Sang, Sung, Myung-Whun, Kim, Kwang Hyun, Park, Chan Il
• Format: Journal Article
• Language: English
• Published: England 01.03.2007
• Subjects: Airway Obstruction - etiology; Animals; Antibiotics, Antineoplastic - adverse effects; Antibiotics, Antineoplastic - therapeutic use; Cause of Death; Cicatrix - etiology; Disease Models, Animal; Female; Mitomycin - adverse effects; Mitomycin - therapeutic use; Necrosis; Rabbits; Random Allocation; Respiratory Mucosa - injuries; Respiratory Mucosa - surgery; Risk Assessment; Rupture, Spontaneous; Suture Techniques; Trachea - injuries; Trachea - surgery; Tracheal Stenosis - etiology
• ISSN: 0194-5998
• DOI: 10.1016/j.otohns.2006.09.012

To investigate the efficacy and early complications of mitomycin C (MMC) in tracheal wound models. Rabbits (N = 60) were randomized to undergo mucosal injuries to the upper and lower trachea including anterior 120 degrees full thickness (group A, n = 20), anterior 120 degrees partial thickness (group B, 20), and circumferential partial thickness (group C, 20). In each rabbit, the wounds were separately treated with MMC 1.0 mg/mL or saline, and the animals were sacrificed after three weeks. Twenty-seven of the 60 animals experienced early death because of tracheal rupture or airway obstruction caused by unresolved scabs on the preinjured tracheal mucosa; the incidence of early death was higher in groups A and C than in group B. In each group, the degree of tracheal stenosis was comparable in wounds treated with MMC and saline. These findings suggest that topical MMC has no benefit when used to prevent tracheal stenosis. Acute airway obstruction may occur in MMC-treated rabbits with tracheal wounds.