Elevated osteopontin levels in active relapsing-remitting multiple sclerosis

• Published in: Annals of neurology Vol. 53; no. 6; pp. 819 - 822
• Main Authors: Vogt, Mario H. J., Lopatinskaya, Luba, Smits, Monique, Polman, Chris H., Nagelkerken, Lex
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2003; Willey-Liss
• Subjects: Biological and medical sciences; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Medical sciences; Middle Aged; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Multiple Sclerosis, Chronic Progressive - metabolism; Multiple Sclerosis, Relapsing-Remitting - metabolism; Neurology; Osteopontin; Sialoglycoproteins - blood; Sialoglycoproteins - metabolism; Human; Nervous system diseases; Multiple sclerosis; Pathogenesis; Central nervous system disease; Osteopontin; Inflammatory disease
• ISSN: 0364-5134; 1531-8249
• DOI: 10.1002/ana.10606

In the search for proteins that might play a role in the pathogenesis of multiple sclerosis (MS), osteopontin (OPN) has been identified as the most prominent cytokine‐encoding gene expressed within MS lesions. Here, we report significantly increased OPN protein levels in plasma of relapsing‐remitting MS patients. In contrast, OPN protein levels in primary progressive and secondary progressive MS patients were similar to healthy control levels. Interestingly, active relapsing‐remitting patients had higher OPN protein levels than patients without relapses. Ann Neurol 2003;53:819–822