Hepatobiliary Complications of Hematopoietic Cell Transplantation, 40 Years On

Liver problems caused by infection, cholestasis and sinusoidal liver injury in the months following HCT have become less frequent because of preventive and pre-emptive strategies. When patients develop jaundice after transplant, the time to search for treatable causes is early in the course of jaund...

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Published inHepatology (Baltimore, Md.) Vol. 51; no. 4; pp. 1450 - 1460
Main Author McDonald, George B.
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2010
Wiley
Subjects
Biliary Tract Diseases - etiology
Biological and medical sciences
Cholestasis - etiology
Gallstones - complications
Gastroenterology. Liver. Pancreas. Abdomen
Graft vs Host Disease - etiology
Hematopoietic Stem Cell Transplantation - adverse effects
Hepatic Veno-Occlusive Disease - etiology
Hepatitis, Viral, Human - complications
Humans
Iron Overload - complications
Liver Diseases - etiology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Mycoses - complications
Hepatobiliary
Treatment
Surgery
Gastroenterology
Hematopoietic cell
Graft
Complication
Transplantation
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Abstract Liver problems caused by infection, cholestasis and sinusoidal liver injury in the months following HCT have become less frequent because of preventive and pre-emptive strategies. When patients develop jaundice after transplant, the time to search for treatable causes is early in the course of jaundice, as the risk of mortality rises steeply with small increments of serum bilirubin above normal. Chronic hepatitis C, persistent GVHD, cirrhosis and hepatocellular carcinoma are significant liver problems in the longest-lived survivors of HCT.
AbstractList Liver problems caused by infection, cholestasis and sinusoidal liver injury in the months following HCT have become less frequent because of preventive and pre-emptive strategies. When patients develop jaundice after transplant, the time to search for treatable causes is early in the course of jaundice, as the risk of mortality rises steeply with small increments of serum bilirubin above normal. Chronic hepatitis C, persistent GVHD, cirrhosis and hepatocellular carcinoma are significant liver problems in the longest-lived survivors of HCT.
Author McDonald, George B.
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Issue 4
Keywords Hepatobiliary
Treatment
Surgery
Gastroenterology
Hematopoietic cell
Graft
Complication
Transplantation
Language English
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Snippet Liver problems caused by infection, cholestasis and sinusoidal liver injury in the months following HCT have become less frequent because of preventive and...
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SubjectTerms Biliary Tract Diseases - etiology
Biological and medical sciences
Cholestasis - etiology
Gallstones - complications
Gastroenterology. Liver. Pancreas. Abdomen
Graft vs Host Disease - etiology
Hematopoietic Stem Cell Transplantation - adverse effects
Hepatic Veno-Occlusive Disease - etiology
Hepatitis, Viral, Human - complications
Humans
Iron Overload - complications
Liver Diseases - etiology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Mycoses - complications
Title Hepatobiliary Complications of Hematopoietic Cell Transplantation, 40 Years On
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fhep.23533
https://www.ncbi.nlm.nih.gov/pubmed/20373370
https://search.proquest.com/docview/733859650
Volume 51
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