Hepatobiliary Complications of Hematopoietic Cell Transplantation, 40 Years On

Liver problems caused by infection, cholestasis and sinusoidal liver injury in the months following HCT have become less frequent because of preventive and pre-emptive strategies. When patients develop jaundice after transplant, the time to search for treatable causes is early in the course of jaund...

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Published inHepatology (Baltimore, Md.) Vol. 51; no. 4; pp. 1450 - 1460
Main Author McDonald, George B.
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2010
Wiley
Subjects
Biliary Tract Diseases - etiology
Biological and medical sciences
Cholestasis - etiology
Gallstones - complications
Gastroenterology. Liver. Pancreas. Abdomen
Graft vs Host Disease - etiology
Hematopoietic Stem Cell Transplantation - adverse effects
Hepatic Veno-Occlusive Disease - etiology
Hepatitis, Viral, Human - complications
Humans
Iron Overload - complications
Liver Diseases - etiology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Mycoses - complications
Hepatobiliary
Treatment
Surgery
Gastroenterology
Hematopoietic cell
Graft
Complication
Transplantation
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Summary:Liver problems caused by infection, cholestasis and sinusoidal liver injury in the months following HCT have become less frequent because of preventive and pre-emptive strategies. When patients develop jaundice after transplant, the time to search for treatable causes is early in the course of jaundice, as the risk of mortality rises steeply with small increments of serum bilirubin above normal. Chronic hepatitis C, persistent GVHD, cirrhosis and hepatocellular carcinoma are significant liver problems in the longest-lived survivors of HCT.
Bibliography:Potential conflict of interest: Nothing to report.
Fax: 206‐667‐6519
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.23533