Birthplace and esophageal cancer incidence patterns among Asian‐Americans

• Published in: Diseases of the esophagus Vol. 29; no. 1; pp. 99 - 104
• Main Authors: Kim, J. Y., Winters, J. K., Kim, J., Bernstein, L., Raz, D., Gomez, S. L.
• Format: Journal Article
• Language: English
• Published: United States 01.01.2016
• Subjects: Adenocarcinoma - ethnology; Adult; Aged; Asian; Asian - statistics & numerical data; Asian‐American; California - epidemiology; Carcinoma, Squamous Cell - ethnology; esophageal neoplasm; Esophageal Neoplasms - ethnology; Esophageal Squamous Cell Carcinoma; ethnology; Female; Humans; Incidence; Male; Middle Aged; residence characteristic; Residence Characteristics - statistics & numerical data; Spatio-Temporal Analysis; trend; Asian-American; ethnology; esophageal neoplasm; trend; Asian; residence characteristic
• ISSN: 1120-8694; 1442-2050; 1442-2050
• DOI: 10.1111/dote.12302

Summary The incidence of esophageal adenocarcinoma in the United States has risen rapidly over the last 30 years, whereas the incidence of esophageal squamous cell carcinoma has fallen dramatically. In contrast, parts of Asia have extremely high rates of squamous cell carcinoma, but virtually no adenocarcinoma. Within the United States, Asian‐Americans as a whole, have low rates of esophageal adenocarcinoma and higher rates of squamous cell carcinoma. It is unclear what the patterns are for those Asians born in the United States. The relative influence of ethnicity and environment on the incidence of esophageal cancer in this population is unknown. We identified all cases of esophageal adenocarcinoma and squamous cell carcinoma from the California Cancer Registry 1988–2004, including 955 cases among 6 different Asian ethnicities. Time trends were examined using Joinpoint software to calculate the annual percentage changes in regression models. Rates of esophageal squamous cell carcinoma varied substantially among different Asian ethnic groups, but squamous cell carcinoma was much more common than adenocarcinoma in both foreign‐born and US‐born Asian‐Americans. Rates of squamous cell carcinoma were slightly higher among US‐born Asian men (4.0 per 100,000) compared with foreign‐born Asian men (3.2 per 100,000) and White men (2.2 per 100,000), P = 0.03. Rates of adenocarcinoma were also slighter higher among US‐born Asian men (1.2 per 100,000) compared with foreign‐born Asian men (0.7 per 100,000), P = 0.01. Rates of squamous cell carcinoma decreased for both US‐born and foreign‐born Asians during this period, whereas adenocarcinoma remained low and stable. These results provide better insight into the genetic and environmental factors affecting the changing incidence of esophageal cancer histologies in the United States and Asia.